{"id":"W2011562061","doi":"10.1182/blood-2009-12-261487","title":"Elucidation of the integrin LFA-1–mediated signaling pathway of actin polarization in natural killer cells","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Vinculin; Phosphatidylinositol; Actin cytoskeleton; Wiskott–Aldrich syndrome protein; Biology; Lymphocyte function-associated antigen 1; Integrin; Actin remodeling; Actin; Cell adhesion; Signal transduction; Focal adhesion; Cytoskeleton; Cell adhesion molecule; Intercellular Adhesion Molecule-1; Receptor; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003041378,0.00007324787,0.0001542963,0.0001500413,0.00001716948,0.000004665384,0.0001244249,0.0001080095,0.0001654014],"category_scores_gemma":[0.0007001714,0.00004989054,0.00005784854,0.0004258329,0.00005774782,0.00003791871,0.00006210914,0.0005168791,0.00000869723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000125683,"about_ca_system_score_gemma":0.0001248186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001183212,"about_ca_topic_score_gemma":0.000075076,"domain_scores_codex":[0.9990147,0.00007485912,0.0002784972,0.0001309253,0.0003699504,0.0001310553],"domain_scores_gemma":[0.9992821,0.0001341176,0.0001236732,0.0002505586,0.0001695272,0.00004001952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004722735,0.0003025855,0.02421445,0.00005181536,0.00001284857,0.000003144458,0.0002307026,0.000003670021,0.9741127,0.00003029566,0.00002042867,0.0009701365],"study_design_scores_gemma":[0.00136675,0.00005561286,0.05511858,0.0000725573,0.00001756147,0.000004013742,0.00008351833,0.0003299585,0.9426895,0.00001150999,0.0002081821,0.00004221251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987393,0.00003237559,0.00002885954,0.0001751836,0.0002322877,0.000308542,0.000002671115,0.000009333998,0.000471461],"genre_scores_gemma":[0.9988267,0.000004363019,0.0004402383,0.00003311297,0.00003498989,0.000004200274,0.00002810042,0.00001314353,0.0006151897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03142315,"threshold_uncertainty_score":0.2245612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009497295817948795,"score_gpt":0.2523052594348749,"score_spread":0.2428079636169261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}