{"id":"W2011586410","doi":"10.1067/mcp.2002.126174","title":"Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker","year":2002,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"","keywords":"CYP2C19; Omeprazole; Menstrual cycle; Medicine; Internal medicine; Endocrinology; Cytochrome P450; Physiology; Hormone; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0028571,0.0007065596,0.00129302,0.000234713,0.0003814338,0.00002598142,0.0005336924,0.0007944289,0.003076573],"category_scores_gemma":[0.00005361006,0.0005646751,0.000311055,0.0004243952,0.00180425,0.0001360723,0.0002053542,0.002192624,0.0002325755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000520295,"about_ca_system_score_gemma":0.00008693167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005959749,"about_ca_topic_score_gemma":0.000001473241,"domain_scores_codex":[0.9926437,0.004140365,0.0009356019,0.000943923,0.0004057827,0.0009306383],"domain_scores_gemma":[0.992801,0.005380222,0.0005416466,0.0004455727,0.000131459,0.0007000681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01108803,0.005445416,0.003274633,0.0001185802,0.003516298,0.0002163245,0.0007801006,0.0001334752,0.7214809,0.00002534945,0.003819773,0.2501011],"study_design_scores_gemma":[0.05729628,0.01371372,0.003384596,0.00003161005,0.005494733,0.0001568861,0.00005615481,0.04330499,0.7198809,0.0001153402,0.1554769,0.001087936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905106,0.00148222,0.00003763279,0.002321997,0.001476068,0.001257528,0.000155364,0.0001420125,0.002616586],"genre_scores_gemma":[0.9787159,0.003349102,0.00006663458,0.01673562,0.0005244116,0.0001150267,0.00001132735,0.00009395766,0.0003880068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2490132,"threshold_uncertainty_score":0.9996805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1853097681112908,"score_gpt":0.5257971988813166,"score_spread":0.3404874307700259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}