{"id":"W2011596047","doi":"10.1016/j.pediatrneurol.2015.01.004","title":"Use of mTOR Inhibitor Everolimus in Three Neonates for Treatment of Tumors Associated With Tuberous Sclerosis Complex","year":2015,"lang":"en","type":"article","venue":"Pediatric Neurology","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Novartis","keywords":"Tuberous sclerosis; Everolimus; Subependymal giant cell astrocytoma; Medicine; Subependymal zone; Sirolimus; PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors; TSC2; Astrocytoma; Pathology; Internal medicine; Glioma; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894952,0.0007612065,0.001002143,0.0007166198,0.001674701,0.0005434818,0.0006770671,0.00230141,0.00054771],"category_scores_gemma":[0.002386777,0.0003083581,0.001570473,0.0003506627,0.000785989,0.0003845279,0.0007054365,0.002745569,0.0001366917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001712404,"about_ca_system_score_gemma":0.001396216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003293676,"about_ca_topic_score_gemma":0.004202059,"domain_scores_codex":[0.9995403,0.00005136362,0.0001144727,0.00009299366,0.00007557224,0.0001252755],"domain_scores_gemma":[0.9991246,0.0001891236,0.0001509611,0.00004250731,0.00006752939,0.0004253454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.000275081,0.0002562186,0.02808899,0.00008127308,0.00006744686,0.9567749,0.000479308,0.00024926,0.003342035,0.0002604444,0.0003473607,0.009777728],"study_design_scores_gemma":[0.00007436494,0.002357045,0.05936631,0.0001019828,0.0001727721,0.925515,0.0008503367,0.0005456251,0.008171158,0.0003122645,0.002472864,0.00006028479],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899456,0.004033448,0.0009164265,0.002769532,0.0002489815,0.00005255174,0.00008470698,0.00004919043,0.001899632],"genre_scores_gemma":[0.9948332,0.001972369,0.0008322623,0.001203692,0.0001351117,0.0000282747,0.0000980922,0.00001787193,0.0008791792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003293676,"threshold_uncertainty_score":0.01242447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2113707334417406,"score_gpt":0.3087271946997734,"score_spread":0.09735646125803282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}