{"id":"W2011602382","doi":"10.1007/s00239-005-0051-1","title":"The Response of Amino Acid Frequencies to Directional Mutation Pressure in Mitochondrial Genome Sequences Is Related to the Physical Properties of the Amino Acids and to the Structure of the Genetic Code","year":2006,"lang":"en","type":"article","venue":"Journal of Molecular Evolution","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Genomics; University of Toronto; Ontario Institute for Cancer Research; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Genetic code; Amino acid; Biology; Mutation; Genetics; Point mutation; Position (finance); Alanine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004107324,0.0001181806,0.0001543585,0.00004357994,0.00014873,0.00001958676,0.000444622,0.00009273367,0.00000165511],"category_scores_gemma":[0.0003935261,0.00004988208,0.0001326116,0.0002401372,0.000166907,0.000008219921,0.0001034732,0.0001286061,2.313214e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000030533,"about_ca_system_score_gemma":0.0001423804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007655613,"about_ca_topic_score_gemma":0.000125562,"domain_scores_codex":[0.9982816,0.0006298683,0.0003936451,0.000142373,0.0004220548,0.0001304886],"domain_scores_gemma":[0.9990128,0.00003773255,0.0003451099,0.0003175854,0.0002594098,0.00002737065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005894066,0.00001989383,0.0003280033,0.00001016496,0.00005563472,5.680715e-7,0.0007422171,0.0108171,0.9870623,0.00008501521,0.00006492556,0.00022475],"study_design_scores_gemma":[0.0001716226,0.0003152763,0.06705499,0.00006044886,0.00005820951,0.00004240379,0.000226178,0.00005969712,0.930452,0.0008195941,0.000679582,0.00006001738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924893,0.002720551,0.001125043,0.00291476,0.0001895074,0.0005136554,0.00003954633,0.0000010664,0.000006513941],"genre_scores_gemma":[0.9992722,0.00001908892,0.0004087053,0.00009047802,0.0001044709,0.00001052438,7.569526e-7,0.000009400159,0.00008433811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06672699,"threshold_uncertainty_score":0.2034132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005101507868000388,"score_gpt":0.2076165799038324,"score_spread":0.202515072035832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}