{"id":"W2011626672","doi":"10.1074/jbc.m112.383794","title":"Scanning the Topography of Polyamine Blocker Binding in an Inwardly Rectifying Potassium Channel*","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Polyamine; Chemistry; Biophysics; Cysteine; Potassium channel; Potassium channel blocker; Channel blocker; Binding site; Biochemistry; Stereochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076355,0.000138474,0.000154498,0.00008690941,0.0001252519,0.0002653823,0.0002074951,0.0002520781,0.0008343562],"category_scores_gemma":[0.0002177067,0.0001264537,0.0001339948,0.0001029307,0.0002094064,0.0001742385,0.0001362938,0.0003513475,0.0002088927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874945,"about_ca_system_score_gemma":0.0001183644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000653115,"about_ca_topic_score_gemma":0.0009816268,"domain_scores_codex":[0.9999204,0.000009202858,0.000004572315,0.00002083185,0.00002646948,0.00001858032],"domain_scores_gemma":[0.9997832,0.00007731075,0.00005995384,0.0000207874,0.00002878348,0.00002995401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002720613,0.000004930711,0.0001173852,0.00000817782,0.000001816675,0.0000135198,0.000006223642,0.00005221488,0.9993677,0.00001812933,0.000004305354,0.0003784618],"study_design_scores_gemma":[0.000004048258,0.0001283187,0.004476801,0.000002093114,0.0000102441,0.0001149793,0.00001715027,0.0009581856,0.9940374,0.00001603736,0.000230299,0.000004454153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965252,0.0002873,0.002498263,0.00002815684,0.00000431865,0.000006592758,0.0000663856,0.0000373498,0.0005464917],"genre_scores_gemma":[0.995478,0.0002704186,0.003312532,0.0000372536,0.000002287618,0.000009722344,0.00009290641,0.00001824893,0.0007787239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008343562,"threshold_uncertainty_score":0.002791166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519209158679037,"score_gpt":0.2588306208348972,"score_spread":0.2336385292481068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}