{"id":"W2011681488","doi":"10.1016/j.bmcl.2009.05.029","title":"Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Chemistry; Tyrosine kinase; Receptor tyrosine kinase; Ephrin; EPH receptor A2; Kinase; Receptor Protein-Tyrosine Kinases; Biochemistry; Cell biology; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102865,0.0002176022,0.0003670089,0.00008991153,0.00009489965,0.00003036004,0.0002270401,0.00006915112,0.0001595655],"category_scores_gemma":[0.0002716209,0.0001841475,0.0001164528,0.0008329615,0.0002692624,0.0001812642,0.00004463464,0.0002110214,0.000002645015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004926759,"about_ca_system_score_gemma":0.00003041232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001381425,"about_ca_topic_score_gemma":4.301996e-7,"domain_scores_codex":[0.9983639,0.00003569452,0.0003744173,0.0004873591,0.0004466819,0.0002919531],"domain_scores_gemma":[0.9992771,0.0001189212,0.0002042492,0.0002470088,0.00002091382,0.0001318748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006006553,0.00001872067,0.001139378,0.00002655062,0.00002955988,0.0000326385,0.00009094632,0.000007793774,0.997459,0.00001408684,0.0003898469,0.0007313998],"study_design_scores_gemma":[0.0003305233,0.00004419397,0.006918905,0.00004891145,0.0002336028,0.00002030486,0.0000512247,0.0001017613,0.9919247,0.0000133236,0.0001308786,0.0001816939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955805,0.0002952681,0.0000927689,0.003723084,0.0001049825,0.00006860749,0.00002810755,0.00003790786,0.00006878351],"genre_scores_gemma":[0.9961132,0.00005660038,0.00003857965,0.003446613,0.000265508,0.000001250334,0.00001390243,0.00001197539,0.00005236502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005779527,"threshold_uncertainty_score":0.7509316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351588916174887,"score_gpt":0.241852296537233,"score_spread":0.2283364073754841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}