{"id":"W2011681488","doi":"10.1016/j.bmcl.2009.05.029","title":"Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Chemistry; Tyrosine kinase; Receptor tyrosine kinase; Ephrin; EPH receptor A2; Kinase; Receptor Protein-Tyrosine Kinases; Biochemistry; Cell biology; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566891,0.0003832125,0.0003757478,0.000267261,0.0002207798,0.0004325909,0.0004192357,0.0001870925,0.001522098],"category_scores_gemma":[0.0001853174,0.0001989062,0.0002672626,0.0001750078,0.0001494349,0.0002565469,0.0001827785,0.0005064037,0.0002862994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000587166,"about_ca_system_score_gemma":0.0004206272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049874,"about_ca_topic_score_gemma":0.00213182,"domain_scores_codex":[0.9999275,0.00001087595,0.00000436222,0.000009129825,0.00002806017,0.00002007165],"domain_scores_gemma":[0.9999713,0.000005118165,0.000008086965,0.000002789649,0.000005986903,0.000006773125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001447305,0.0005671856,0.000916254,0.000354608,0.0001175944,0.00114138,0.0001102119,0.02723773,0.8917426,0.01251291,0.002384526,0.0614677],"study_design_scores_gemma":[0.0003847576,0.001512728,0.001422774,0.00003547092,0.0001391459,0.0009972041,0.00006912577,0.02349961,0.9391348,0.001318471,0.03145009,0.00003575932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588364,0.01186426,0.01324119,0.0009276677,0.00011857,0.0002286937,0.001154331,0.0001868513,0.01344195],"genre_scores_gemma":[0.9781345,0.008122656,0.007313386,0.0001710133,0.00002041626,0.00004270378,0.001103263,0.00002573355,0.005066327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522098,"threshold_uncertainty_score":0.005091906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351588916174887,"score_gpt":0.241852296537233,"score_spread":0.2283364073754841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}