{"id":"W2011691625","doi":"10.1210/en.2012-1720","title":"Susceptibility to Fatty Acid-Induced β-Cell Dysfunction Is Enhanced in Prediabetic Diabetes-Prone BioBreeding Rats: A Potential Link Between β-Cell Lipotoxicity and Islet Inflammation","year":2012,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia; Western University; Lawson Health Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; University Health Network","keywords":"Internal medicine; Endocrinology; Lipotoxicity; Insulitis; Islet; Insulin resistance; Diabetes mellitus; Beta cell; Medicine; Insulin; Cytokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002757696,0.0008627471,0.0005531476,0.001080822,0.0002670942,0.0004526282,0.0002510458,0.0005129764,0.001891997],"category_scores_gemma":[0.0002093546,0.0003939834,0.0003485429,0.0003161806,0.0004396352,0.0003389384,0.0003891243,0.001315333,0.0002540692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495245,"about_ca_system_score_gemma":0.0001822098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004765525,"about_ca_topic_score_gemma":0.0009287099,"domain_scores_codex":[0.9997339,0.00003189705,0.00003016087,0.0001017827,0.00004249232,0.00005972416],"domain_scores_gemma":[0.9994259,0.00004136833,0.0002061756,0.00006794684,0.00002908273,0.0002295438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004906976,0.0001369815,0.0017243,0.00002420125,0.00001077369,0.0001154358,0.00003704061,0.00001281216,0.9965389,0.00003977043,0.00001379701,0.000855162],"study_design_scores_gemma":[0.0001686639,0.00479152,0.1811185,0.00004559877,0.0002137596,0.002329688,0.0005599045,0.0006216298,0.8082157,0.0002835882,0.001602669,0.00004878448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986516,0.000241559,0.0006989359,0.00004076689,0.000009277528,0.00001250476,0.0001267828,0.00002271591,0.0001959476],"genre_scores_gemma":[0.9957833,0.0005802258,0.001713819,0.0001353849,0.00001856092,0.00006605204,0.0003765792,0.00003903055,0.001287037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001891997,"threshold_uncertainty_score":0.006329358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933112116863353,"score_gpt":0.2551492806115889,"score_spread":0.2358181594429553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}