{"id":"W2011698658","doi":"10.1002/art.11247","title":"Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction","year":2003,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Cartilage; Matrix metalloproteinase; Chondrocyte; Collagenase; Chemistry; Extracellular matrix; Metalloproteinase; Type II collagen; Osteoarthritis; Aggrecan; Molecular biology; Gene expression; Endothelin 1; Synovial membrane; Cell biology; Biochemistry; Enzyme; Biology; Inflammation; Immunology; Pathology; Receptor; Medicine; Gene; In vitro; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006540021,0.0006040427,0.0008787035,0.0003703448,0.000415682,0.0001652162,0.0001006614,0.0002915094,0.0009830975],"category_scores_gemma":[0.0004827201,0.0005966944,0.0002495626,0.0003600449,0.0001987591,0.0008136584,0.00005579663,0.0003772942,0.000352138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001133978,"about_ca_system_score_gemma":0.0002074993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002048144,"about_ca_topic_score_gemma":0.0004538424,"domain_scores_codex":[0.9965434,0.0003220957,0.0008813935,0.0008541538,0.0006538645,0.0007450596],"domain_scores_gemma":[0.9982166,0.0001115124,0.0002810384,0.0006375053,0.0001924241,0.0005609399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002560747,0.0009300013,0.001430916,0.0003947596,0.000199936,0.0007864494,0.001206387,0.000003438099,0.5286725,0.01495029,0.0001123591,0.4510568],"study_design_scores_gemma":[0.04819894,0.009147595,0.00123785,0.005055812,0.001344124,0.01534508,0.001772,0.0002614238,0.8777618,0.02990265,0.007330214,0.002642528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670577,0.02604857,0.001390103,0.0004605794,0.0004768836,0.003229653,0.00007353327,0.000361813,0.0009011902],"genre_scores_gemma":[0.9759408,0.0027944,0.01732892,0.0001153454,0.00008101352,0.0006783329,0.0002053474,0.0001200635,0.002735784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4484143,"threshold_uncertainty_score":0.9999301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196347827332723,"score_gpt":0.248749119023517,"score_spread":0.2367856407501898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}