{"id":"W2011698658","doi":"10.1002/art.11247","title":"Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction","year":2003,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Cartilage; Matrix metalloproteinase; Chondrocyte; Collagenase; Chemistry; Extracellular matrix; Metalloproteinase; Type II collagen; Osteoarthritis; Aggrecan; Molecular biology; Gene expression; Endothelin 1; Synovial membrane; Cell biology; Biochemistry; Enzyme; Biology; Inflammation; Immunology; Pathology; Receptor; Medicine; Gene; In vitro; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197094,0.0003492688,0.0002542562,0.0003705787,0.0001468148,0.0002138718,0.000121792,0.0002355242,0.002599611],"category_scores_gemma":[0.0002285459,0.0001500084,0.000451747,0.000183411,0.0002458934,0.0001820148,0.0001833622,0.0004672891,0.0003396243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162195,"about_ca_system_score_gemma":0.0001719889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003679147,"about_ca_topic_score_gemma":0.0007780559,"domain_scores_codex":[0.9997762,0.00003708207,0.00001851222,0.00002662998,0.00009101788,0.00005053588],"domain_scores_gemma":[0.9997999,0.00004567187,0.00006980958,0.00001192771,0.0000284356,0.00004414629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001762876,0.00004084962,0.0002562586,0.00007951983,0.000005663767,0.0001059552,0.00001512297,0.00002767811,0.9982798,0.00002050099,0.00002096361,0.0009712972],"study_design_scores_gemma":[0.0001504637,0.002195081,0.05397954,0.00004643728,0.00005875223,0.001134072,0.0001093196,0.0008960838,0.9390069,0.0001372627,0.00227333,0.000012756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894556,0.006337629,0.002253737,0.0001127411,0.00005602411,0.00004111633,0.0002269526,0.00005024474,0.001465948],"genre_scores_gemma":[0.9906952,0.003096095,0.002009437,0.00008418599,0.00004981903,0.00006170366,0.0002532629,0.000008842801,0.003741353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002599611,"threshold_uncertainty_score":0.008696496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196347827332723,"score_gpt":0.248749119023517,"score_spread":0.2367856407501898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}