{"id":"W2011700223","doi":"10.1038/nature714","title":"Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas","year":2002,"lang":"en","type":"article","venue":"Nature","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"National Institutes of Health; Cancer Research Institute; Howard Hughes Medical Institute","keywords":"Somatic hypermutation; Cytidine deaminase; Activation-induced (cytidine) deaminase; Germinal center; Cytidine; Biology; B cell; Somatic cell; Immunoglobulin class switching; Antibody; Point mutation; Mutation; Affinity maturation; Molecular biology; Gene; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003973636,0.0002943184,0.0002443712,0.0004735838,0.0002678641,0.0005508103,0.0003240176,0.000508878,0.002553881],"category_scores_gemma":[0.0004259376,0.0002792391,0.0002822643,0.0002280322,0.000252905,0.0002317319,0.0004521652,0.0007973763,0.00066273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415815,"about_ca_system_score_gemma":0.0001230714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002609613,"about_ca_topic_score_gemma":0.000435015,"domain_scores_codex":[0.9996271,0.0001015349,0.00002395616,0.00004988089,0.000104586,0.00009288464],"domain_scores_gemma":[0.9996032,0.0001961472,0.00004602514,0.00007022416,0.00003811989,0.00004628732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005497,0.00001916772,0.000278269,0.00001276112,0.000007280818,0.0001324867,0.00001814451,0.00008461776,0.9972864,0.0004676438,0.00006731663,0.001525355],"study_design_scores_gemma":[0.00001850064,0.0001036571,0.001442019,0.000003602541,0.00001188539,0.0005081886,0.00001448953,0.000728748,0.995237,0.000188518,0.001738631,0.000004720882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880381,0.000611368,0.005149246,0.000110954,0.00007740199,0.00002990642,0.0001093203,0.0001626242,0.005711171],"genre_scores_gemma":[0.9966354,0.0002160496,0.001061496,0.00005351531,0.00001457865,0.00001455601,0.0001368959,0.00006426242,0.001803294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553881,"threshold_uncertainty_score":0.008543551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03357012608040896,"score_gpt":0.3197307620285859,"score_spread":0.2861606359481769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}