{"id":"W2011711371","doi":"10.1073/pnas.1013388108","title":"Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan; Canadian Light Source","keywords":"ISG15; Deubiquitinating enzyme; Ubiquitin; Biology; Proteases; Interferon-stimulated gene; Viral protein; Protease; Interferon; Gene; Ubiquitins; Cell biology; Innate immune system; Virology; Biochemistry; Virus; Enzyme; Genetics; Ubiquitin ligase; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007796978,0.0002569763,0.0002055418,0.0001047618,0.0002652215,0.000346803,0.000392887,0.0003556398,0.0006043738],"category_scores_gemma":[0.000135083,0.0001639988,0.0003170134,0.0001115343,0.000273083,0.0002294603,0.0002010718,0.0004451395,0.000262551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007800422,"about_ca_system_score_gemma":0.0004288361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002061705,"about_ca_topic_score_gemma":0.001478052,"domain_scores_codex":[0.999934,0.000008244263,0.000005652668,0.00001363556,0.00002218225,0.00001633249],"domain_scores_gemma":[0.9999334,0.000005848006,0.00002647718,0.000006085466,0.000006234093,0.00002200319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002643525,0.00007723847,0.002215705,0.00007450712,0.00002828556,0.001025785,0.00007759545,0.001808978,0.9904264,0.002248332,0.0001162937,0.001636453],"study_design_scores_gemma":[0.0001233364,0.0004188256,0.03540923,0.00003418566,0.0000557091,0.002669045,0.0002249649,0.02463521,0.928028,0.0009832876,0.007381996,0.00003606426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970726,0.0004704815,0.001191406,0.00006798925,0.00001579949,0.00001394842,0.00005508489,0.00002109095,0.001091574],"genre_scores_gemma":[0.9976164,0.0002255159,0.001319527,0.00005059976,0.00000436778,0.00000732088,0.000219736,0.000005384905,0.000551056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061705,"threshold_uncertainty_score":0.00565964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05674751495943762,"score_gpt":0.3093210207724628,"score_spread":0.2525735058130252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}