{"id":"W2011711371","doi":"10.1073/pnas.1013388108","title":"Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan; Canadian Light Source","keywords":"ISG15; Deubiquitinating enzyme; Ubiquitin; Biology; Proteases; Interferon-stimulated gene; Viral protein; Protease; Interferon; Gene; Ubiquitins; Cell biology; Innate immune system; Virology; Biochemistry; Virus; Enzyme; Genetics; Ubiquitin ligase; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008769444,0.00008539783,0.0001683169,0.0001000247,0.0002001406,0.00001110576,0.0002273854,0.00004719854,0.00002368988],"category_scores_gemma":[0.0004322685,0.00004535235,0.00007337732,0.0002974627,0.0006983985,0.000202239,0.00007473092,0.0001219063,9.458925e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002421663,"about_ca_system_score_gemma":0.00003575984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005595408,"about_ca_topic_score_gemma":1.504083e-7,"domain_scores_codex":[0.9990347,0.000005475849,0.0002977493,0.0001642056,0.0003730214,0.0001248304],"domain_scores_gemma":[0.9992852,0.0000886996,0.0003311683,0.000009635516,0.0002497391,0.00003561925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007259099,0.00006092149,0.01337137,0.0001524132,0.00009574676,4.960764e-8,0.00149982,0.00001076411,0.95838,0.02427189,0.0002397412,0.001191354],"study_design_scores_gemma":[0.001191571,0.001186324,0.09964431,0.0002533587,0.0001122485,0.0001993458,0.001143211,0.007702708,0.8666555,0.02163967,0.0001426684,0.0001291185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974883,0.0001308368,0.00001287029,0.0009654855,0.00001801656,0.0005156019,0.00002877518,0.000007767373,0.0008323247],"genre_scores_gemma":[0.9951162,0.000003109461,0.004576484,0.0001768248,0.00005030245,0.00002068475,2.205231e-7,0.000004432179,0.00005177341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09172455,"threshold_uncertainty_score":0.2573278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05674751495943762,"score_gpt":0.3093210207724628,"score_spread":0.2525735058130252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}