{"id":"W2011712807","doi":"10.1182/blood-2008-12-192054","title":"Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":339,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Institute of Genetics; National Cancer Institute; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Terry Fox Foundation; BC Cancer Agency; Austrian Science Fund; Michael Smith Health Research BC; Stem Cell Network","keywords":"Stem cell; Biology; Haematopoiesis; Cell biology; Induced pluripotent stem cell; CXCR4; Stem cell theory of aging; Immunology; Bone marrow; Genetics; Stem cell factor; Embryonic stem cell; Gene; Immune system; Chemokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006669962,0.0001177584,0.0002196983,0.00006982993,0.00003135416,0.00001287336,0.00002638741,0.00007033101,0.00001177554],"category_scores_gemma":[0.000001272404,0.0001010667,0.0000280209,0.0001450291,0.00002115602,0.00008045122,0.000003585621,0.00005957877,0.000003591969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001255062,"about_ca_system_score_gemma":0.00004530931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003053395,"about_ca_topic_score_gemma":4.052702e-7,"domain_scores_codex":[0.9991992,0.00002455623,0.0002181276,0.0002028029,0.0002272,0.0001281104],"domain_scores_gemma":[0.9995748,0.00000930124,0.0001103676,0.0001383072,0.0001013827,0.00006584894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249932,0.000419537,0.007803253,0.0002616873,0.00007027372,0.00005558438,0.001025117,0.000004395721,0.9898612,0.0002854402,5.111864e-7,0.00008798838],"study_design_scores_gemma":[0.003497504,0.0006971614,0.0390981,0.0002079435,0.0005214538,0.0003552143,0.00007997193,0.0001990162,0.9551482,0.00008531363,0.000001802504,0.0001083852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911585,0.00003849113,0.007396839,0.0001223655,0.00002146584,0.0005911484,0.000005918543,0.00006179221,0.0006034265],"genre_scores_gemma":[0.9977882,0.00003400629,0.002001272,0.00004693816,0.00002287078,0.000008959711,0.00002608543,0.00001467297,0.0000570247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03471309,"threshold_uncertainty_score":0.4121382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003654790148121671,"score_gpt":0.1936247957300124,"score_spread":0.1899700055818907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}