{"id":"W2011749905","doi":"10.1074/jbc.m114.605808","title":"Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; University of California, San Francisco; American Heart Association; March of Dimes Foundation","keywords":"Steroidogenic acute regulatory protein; Endoplasmic reticulum; Voltage-dependent anion channel; Mitochondrion; Cholesterol side-chain cleavage enzyme; Cell biology; Biology; Pregnenolone; Inner mitochondrial membrane; Mitochondrial membrane transport protein; Biochemistry; Chemistry; Hormone; Metabolism; Messenger RNA; Bacterial outer membrane; Cytochrome P450; Steroid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016854,0.0002803264,0.0002873769,0.0002029663,0.0004170132,0.0005373965,0.0002170921,0.0004800663,0.001622298],"category_scores_gemma":[0.0002165381,0.000138838,0.0004138886,0.000179256,0.0002354176,0.0005806285,0.0004659347,0.0005288031,0.0005271939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004615053,"about_ca_system_score_gemma":0.0002636694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003823847,"about_ca_topic_score_gemma":0.000585814,"domain_scores_codex":[0.9997631,0.00003352214,0.00002280692,0.0000662707,0.00005341275,0.00006098322],"domain_scores_gemma":[0.9998389,0.00001381195,0.00004908009,0.00001146226,0.00003978647,0.00004682308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000195762,0.0000168667,0.001499948,0.000128893,0.00001265486,0.0001514881,0.00003344701,0.00006416956,0.9956576,0.0004470236,0.0002312982,0.001560878],"study_design_scores_gemma":[0.00007552974,0.0002847073,0.03649381,0.00004228318,0.00008390965,0.001827625,0.0003272451,0.005899502,0.9357936,0.0007589348,0.01838089,0.00003210577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663576,0.0137415,0.01363687,0.0008737362,0.000418605,0.00004474094,0.0008892845,0.0003983461,0.00363932],"genre_scores_gemma":[0.9911867,0.002468727,0.002393788,0.0001491574,0.00003930571,0.00002530927,0.0006455454,0.00002622248,0.003065238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622298,"threshold_uncertainty_score":0.005427122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009488266228920662,"score_gpt":0.2276430349299613,"score_spread":0.2181547687010407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}