{"id":"W2011749905","doi":"10.1074/jbc.m114.605808","title":"Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; University of California, San Francisco; American Heart Association; March of Dimes Foundation","keywords":"Steroidogenic acute regulatory protein; Endoplasmic reticulum; Voltage-dependent anion channel; Mitochondrion; Cholesterol side-chain cleavage enzyme; Cell biology; Biology; Pregnenolone; Inner mitochondrial membrane; Mitochondrial membrane transport protein; Biochemistry; Chemistry; Hormone; Metabolism; Messenger RNA; Bacterial outer membrane; Cytochrome P450; Steroid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005411629,0.0004895173,0.0006447708,0.00006079146,0.0001503116,0.00007648432,0.0005128626,0.0006771382,0.0001138734],"category_scores_gemma":[0.0004735758,0.0003852007,0.0005864099,0.000126975,0.0002107162,0.00003519926,0.0002352463,0.0005782328,0.0000100496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243392,"about_ca_system_score_gemma":0.00009850936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007828349,"about_ca_topic_score_gemma":0.000004273968,"domain_scores_codex":[0.9972109,0.00028711,0.0008320413,0.000651209,0.0004604675,0.0005582501],"domain_scores_gemma":[0.9975179,0.00006414141,0.00113765,0.0005511592,0.0003160711,0.0004130159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130235,0.000414758,0.0004369107,0.00006779208,0.0003962324,0.00004661601,0.00001696683,0.0001049987,0.9963405,0.000002057804,0.0002397374,0.0006311129],"study_design_scores_gemma":[0.002186288,0.0009210818,0.001622093,0.0001287867,0.0001515111,0.000416284,0.00006173044,0.000461722,0.992933,0.000156393,0.000516104,0.0004449605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975051,0.0004607327,0.0008908232,0.000133853,0.0004008527,0.0002930077,0.0000541894,0.00003327057,0.0002282235],"genre_scores_gemma":[0.9979963,0.0002624893,0.0001339887,0.00009489595,0.0007083616,0.00002822053,0.0001313092,0.00004309575,0.0006013896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003407422,"threshold_uncertainty_score":0.99986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009488266228920662,"score_gpt":0.2276430349299613,"score_spread":0.2181547687010407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}