{"id":"W2011756788","doi":"10.1038/srep03372","title":"Hematopoietic Stem and Progenitor Cells Acquire Distinct DNA-Hypermethylation During in vitro Culture","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Stem Cell Network; Deutsches Krebsforschungszentrum","keywords":"DNA methylation; Biology; Stem cell; CD34; Mesenchymal stem cell; dNaM; Haematopoiesis; Progenitor cell; CpG site; Molecular biology; In vitro; Cell biology; Stromal cell; Cancer research; Gene; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872478,0.0001860385,0.0002334657,0.000131709,0.000150365,0.0002129753,0.0001575557,0.0001118343,0.0006341675],"category_scores_gemma":[0.000180296,0.0001082638,0.000137697,0.0001588228,0.0001741827,0.0001124682,0.0002293923,0.0004334809,0.0002515806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001180641,"about_ca_system_score_gemma":0.000156596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005811282,"about_ca_topic_score_gemma":0.001041387,"domain_scores_codex":[0.9998574,0.00003100966,0.00001651774,0.00002652597,0.0000479589,0.00002054124],"domain_scores_gemma":[0.9998914,0.00003676353,0.00001791277,0.00001852957,0.00001770668,0.00001761546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004605611,0.000006894,0.0005051008,0.00001950466,0.00000521758,0.00002317815,0.0000261711,0.00004296006,0.9981983,0.00002205056,0.00001271255,0.001091744],"study_design_scores_gemma":[0.000002127425,0.00009519582,0.005936145,0.000002719397,0.00001346737,0.0000901927,0.00001706591,0.0001648783,0.992703,0.00002423118,0.0009490344,0.000001966043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829885,0.002105088,0.01209017,0.00005974408,0.00001874703,0.00005011572,0.0007018492,0.00007046115,0.001915302],"genre_scores_gemma":[0.9833114,0.001632947,0.0108737,0.00006361977,0.00001821382,0.0001009691,0.001835731,0.00003162913,0.002131802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006341675,"threshold_uncertainty_score":0.002121508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00669078149475045,"score_gpt":0.2201248809460444,"score_spread":0.213434099451294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}