{"id":"W2011780255","doi":"10.1038/nchembio.1257","title":"Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Kinase; Protein kinase domain; Transactivation; Chemistry; Cell biology; Protein kinase A; Biochemistry; Förster resonance energy transfer; Allosteric regulation; Enzyme; Biology; Transcription factor; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042334,0.000190027,0.000177265,0.00004278727,0.00004661958,0.00001462617,0.000185188,0.001137981,0.0001069136],"category_scores_gemma":[0.0002317886,0.0001564866,0.00008208455,0.00009666826,0.0001206675,0.00001015052,0.0001095533,0.0003380243,0.0000558611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000198518,"about_ca_system_score_gemma":0.00004411025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001183783,"about_ca_topic_score_gemma":0.000002721399,"domain_scores_codex":[0.9989887,0.00006864709,0.0002228197,0.0003463223,0.00008625184,0.0002872066],"domain_scores_gemma":[0.9993588,0.00003377744,0.0001104332,0.0002802151,0.0001047171,0.000112074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004259429,0.00003530128,0.001213966,0.00001220412,0.00001571588,4.479236e-7,0.00004692173,2.022073e-7,0.991284,0.0007580586,0.00398224,0.002608371],"study_design_scores_gemma":[0.0006318978,0.00009063668,0.0006411016,0.000006483117,0.000006376276,0.000008099478,0.00006699846,0.000007507507,0.9553207,0.001224823,0.04179446,0.0002009387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965503,0.0005953339,0.0003732479,0.0003981812,0.0004030973,0.0003123496,0.0000307264,0.00003348926,0.001303304],"genre_scores_gemma":[0.9957508,0.00003847749,0.0009193628,0.0008823887,0.0003894832,0.0000580931,0.001914178,0.00001619484,0.00003102389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03781222,"threshold_uncertainty_score":0.8777151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006135531041005006,"score_gpt":0.2266890136289216,"score_spread":0.2205534825879166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}