{"id":"W2011780255","doi":"10.1038/nchembio.1257","title":"Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Kinase; Protein kinase domain; Transactivation; Chemistry; Cell biology; Protein kinase A; Biochemistry; Förster resonance energy transfer; Allosteric regulation; Enzyme; Biology; Transcription factor; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130131,0.0004096684,0.0003708311,0.0002590732,0.0003905132,0.0005605122,0.0003163485,0.0003876596,0.003113059],"category_scores_gemma":[0.0003341094,0.0002811999,0.0004306537,0.0001520446,0.0003673428,0.0003070637,0.0002515295,0.001260301,0.0007081571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000500504,"about_ca_system_score_gemma":0.0002215948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003718614,"about_ca_topic_score_gemma":0.0006523986,"domain_scores_codex":[0.9997218,0.00004687845,0.0000249671,0.00005053593,0.00007864345,0.0000771534],"domain_scores_gemma":[0.9997484,0.00007176797,0.00005731191,0.0000360647,0.0000249007,0.00006157566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001454594,0.00009389368,0.0000869451,0.00003406216,0.00002343209,0.00003826937,0.00001292534,0.0001915568,0.9974641,0.000427623,0.0002106633,0.001271067],"study_design_scores_gemma":[0.00005176893,0.0001164724,0.0006022521,0.000003518417,0.0000137081,0.00012875,0.000009504792,0.0009678338,0.9961732,0.000105876,0.001821147,0.000006066145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831495,0.001622873,0.006674062,0.000335508,0.0001608067,0.0001057075,0.0002939528,0.000297305,0.007360278],"genre_scores_gemma":[0.996075,0.0004038056,0.001142504,0.0001591784,0.00001570911,0.00003374017,0.0002442268,0.00003850188,0.001887267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003113059,"threshold_uncertainty_score":0.01041424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006135531041005006,"score_gpt":0.2266890136289216,"score_spread":0.2205534825879166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}