{"id":"W2011784577","doi":"10.1021/la204833h","title":"Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing","year":2012,"lang":"en","type":"article","venue":"Langmuir","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"POPC; Triolein; Micromixer; Chemistry; Aqueous solution; Monolayer; Bilayer; Chemical engineering; Microfluidics; Analytical Chemistry (journal); Chromatography; Nanotechnology; Organic chemistry; Materials science; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002470274,0.0003170218,0.0002397262,0.0001912259,0.0001462965,0.0003473594,0.0002781951,0.0002519457,0.0004497902],"category_scores_gemma":[0.00024419,0.000268427,0.0002682502,0.0001160124,0.000209001,0.0003421669,0.0003731158,0.0003949519,0.0003760144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004950836,"about_ca_system_score_gemma":0.000271486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000234836,"about_ca_topic_score_gemma":0.000482098,"domain_scores_codex":[0.9998548,0.00001487901,0.00001796304,0.00004153745,0.00005144406,0.00001921569],"domain_scores_gemma":[0.9999141,0.00001928119,0.00003182825,0.000009553477,0.0000140944,0.00001117372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002140606,0.000009124146,0.00006273951,0.00003738182,0.000003094341,0.00002612819,0.00001722097,0.0003710501,0.9952814,0.0005332946,0.00003611679,0.003601184],"study_design_scores_gemma":[0.000006679316,0.00006610978,0.0001427485,0.000001952593,0.000003803336,0.00003288562,0.000003459798,0.002376761,0.995213,0.00006320524,0.002084743,0.000004554129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7759761,0.002695902,0.2144286,0.0002392085,0.0001075655,0.0003306184,0.0003497626,0.0007686646,0.005103589],"genre_scores_gemma":[0.8174355,0.001538748,0.1769641,0.00009641125,0.00003078325,0.0004733428,0.0002640848,0.00009025622,0.003106792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004950836,"threshold_uncertainty_score":0.003592134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599978075153505,"score_gpt":0.2301399094461417,"score_spread":0.2141401286946067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}