{"id":"W2011795666","doi":"10.1016/j.eplepsyres.2008.07.021","title":"Re: Epilepsy Res 2008;79(May (2–3)):97–104","year":2008,"lang":"en","type":"article","venue":"Epilepsy Research","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Active site; Chalcone; Stereochemistry; Hydrazone; Quantitative structure–activity relationship; Moiety; Aldol condensation; Docking (animal); Biological activity; Hydrazide; Pyridine; Pharmacophore; Combinatorial chemistry; Enzyme; Medicinal chemistry; Organic chemistry; Biochemistry; Catalysis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.006603981,0.000320543,0.0004365111,0.0008340671,0.001091688,0.000341648,0.003183204,0.0001852433,0.0004785118],"category_scores_gemma":[0.002083464,0.0003087407,0.0002150194,0.003060056,0.0006477325,0.001120528,0.001686506,0.001249691,0.003276858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675345,"about_ca_system_score_gemma":0.001062642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003117841,"about_ca_topic_score_gemma":0.00004652117,"domain_scores_codex":[0.991199,0.00254482,0.0006433229,0.001291768,0.002905653,0.001415403],"domain_scores_gemma":[0.9925525,0.004081525,0.0001164766,0.001927238,0.0008309429,0.0004913172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002827468,0.0009973856,0.04447539,0.000122553,0.0001529295,0.001785173,0.006209297,0.009279715,0.001380551,0.196128,0.606353,0.1328333],"study_design_scores_gemma":[0.002970494,0.001204381,0.2125369,0.0002338716,0.00001215744,0.0004704063,0.0005174434,0.1301489,0.01104951,0.1386865,0.5002164,0.001953081],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3430813,0.003360735,0.4413212,0.03341264,0.003176511,0.002184686,0.00005130909,0.001290095,0.1721216],"genre_scores_gemma":[0.8585556,0.0004386332,0.1251566,0.0006803411,0.0009081874,0.0001808729,0.00002447876,0.00006926641,0.01398597],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5154743,"threshold_uncertainty_score":0.9999365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1781261300932379,"score_gpt":0.4217005645802835,"score_spread":0.2435744344870457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}