{"id":"W2011817914","doi":"10.1093/mutage/geu045","title":"The expanding role of mTOR in cancer cell growth and proliferation","year":2015,"lang":"en","type":"review","venue":"Mutagenesis","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; mTORC1; RPTOR; Mechanistic target of rapamycin; P70-S6 Kinase 1; mTORC2; Cell growth; Cell biology; Biology; RHEB; Kinase; Protein kinase B; Ribosomal s6 kinase; Ribosomal protein s6; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002913007,0.0002114688,0.0004468928,0.00003624719,0.00005104514,0.00002480817,0.0002031763,0.0002464636,0.000006452992],"category_scores_gemma":[0.00004171533,0.0001515558,0.0001026506,0.00009742471,0.00005391871,0.000003234653,0.0000977387,0.00007461943,0.000001086277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007184839,"about_ca_system_score_gemma":0.0003526726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000151612,"about_ca_topic_score_gemma":0.0001438053,"domain_scores_codex":[0.9989156,0.0001267616,0.0003304111,0.0003120624,0.000132463,0.0001826644],"domain_scores_gemma":[0.9993719,0.00002922513,0.0002292322,0.0002558615,0.00006474098,0.00004902629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004835094,0.00006221468,0.0008699391,0.006320809,0.0001832948,0.000002789433,0.0001868671,0.00001863816,0.03195658,0.00002810978,0.0007705263,0.9595519],"study_design_scores_gemma":[0.0002312152,0.0001052673,0.00001726486,0.0009088147,0.0002119633,0.000004893381,0.00006034246,0.00001157702,0.04270188,0.00002294611,0.9554203,0.0003035346],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005436732,0.9936286,0.000009755206,0.000006211426,0.0001608017,0.0003752684,0.00004957435,0.000004363157,0.0003286459],"genre_scores_gemma":[0.009980881,0.9890746,0.00005410092,0.00001127415,0.0003015779,0.0002908964,0.00004854162,0.00004072484,0.0001973772],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9592484,"threshold_uncertainty_score":0.6180266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981736225017031,"score_gpt":0.3292818160140875,"score_spread":0.2994644537639172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}