{"id":"W2011829725","doi":"10.1016/j.phytochem.2009.03.015","title":"Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor","year":2009,"lang":"en","type":"article","venue":"Phytochemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Taiwan University; Beef Cattle Research Council; National Science Council","keywords":"Lactone; DEPT; Stereochemistry; Chemistry; Sesquiterpene lactone; Two-dimensional nuclear magnetic resonance spectroscopy; Aspergillus niger; Activator (genetics); Biological activity; Heteronuclear single quantum coherence spectroscopy; Carbon-13 NMR; Sesquiterpene; Biochemistry; Receptor; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378971,0.00008088523,0.0001362228,0.00001270528,0.0000523381,0.000007227554,0.00002977001,0.00008747647,0.00003789039],"category_scores_gemma":[0.0001930392,0.00004785085,0.00005368737,0.00006231324,0.00002326745,0.00005794381,0.000002256209,0.00008899673,4.837386e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001887633,"about_ca_system_score_gemma":0.00002221916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.511025e-7,"about_ca_topic_score_gemma":1.709421e-7,"domain_scores_codex":[0.9994543,0.00001627007,0.0001895859,0.0001297756,0.0001119626,0.00009809788],"domain_scores_gemma":[0.9996347,0.00003599525,0.00006813329,0.00006374738,0.0001697807,0.00002766587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840659,0.00003627393,0.00002020336,0.0001457932,0.000009118809,7.484397e-8,0.0001997864,3.498741e-7,0.9704023,0.00001981345,0.00004317305,0.02893904],"study_design_scores_gemma":[0.0006549428,0.0001383546,0.003023895,0.00008951008,0.00006366368,0.00001415521,0.00009785486,0.0003296383,0.9952999,0.00008632806,0.000142756,0.00005894939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994962,0.001012197,0.00006275175,0.002912961,0.00002136122,0.0007195477,0.00004403349,0.0000149278,0.0002502658],"genre_scores_gemma":[0.9994506,0.00007185288,0.00007993346,0.0001444251,0.0001613121,0.000004453317,0.00006311254,0.000003113471,0.00002118855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02888009,"threshold_uncertainty_score":0.1951301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05387332938090369,"score_gpt":0.3025404064664219,"score_spread":0.2486670770855182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}