{"id":"W2011829725","doi":"10.1016/j.phytochem.2009.03.015","title":"Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor","year":2009,"lang":"en","type":"article","venue":"Phytochemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Taiwan University; Beef Cattle Research Council; National Science Council","keywords":"Lactone; DEPT; Stereochemistry; Chemistry; Sesquiterpene lactone; Two-dimensional nuclear magnetic resonance spectroscopy; Aspergillus niger; Activator (genetics); Biological activity; Heteronuclear single quantum coherence spectroscopy; Carbon-13 NMR; Sesquiterpene; Biochemistry; Receptor; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276768,0.0003437728,0.0001744202,0.0003215962,0.0002019366,0.0002876681,0.000274837,0.0002565273,0.001228429],"category_scores_gemma":[0.0001474038,0.0001239998,0.0002946474,0.0003190323,0.0002497856,0.0001698031,0.0001491435,0.0004983708,0.0002175594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435465,"about_ca_system_score_gemma":0.0003803707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00218352,"about_ca_topic_score_gemma":0.002369671,"domain_scores_codex":[0.9998603,0.00003265034,0.00001082528,0.00001703013,0.00003874267,0.0000404737],"domain_scores_gemma":[0.9998808,0.00003948829,0.00001716659,0.00001589572,0.00001720448,0.00002948901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919494,0.00005278242,0.0000663641,0.00001214956,0.000002859642,0.00003286179,0.000009882438,0.00007145466,0.9987462,0.00007777233,0.0000136707,0.0007221167],"study_design_scores_gemma":[0.000007727495,0.000202653,0.0003048969,8.787733e-7,0.000005292822,0.0000336763,0.000007199466,0.000200551,0.9987872,0.000009882176,0.0004385647,0.000001469579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935522,0.001576896,0.002584959,0.00008246393,0.0000314337,0.00002788441,0.0002934086,0.00004998562,0.001800738],"genre_scores_gemma":[0.9958537,0.0005069801,0.00101787,0.00001753928,0.000006296118,0.00001244537,0.0004966193,0.00001023881,0.002078464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218352,"threshold_uncertainty_score":0.004341602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05387332938090369,"score_gpt":0.3025404064664219,"score_spread":0.2486670770855182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}