{"id":"W2011861091","doi":"10.1002/jcb.10052","title":"Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells: Beyond efficiency issues","year":2002,"lang":"en","type":"review","venue":"Journal of Cellular Biochemistry","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Transduction (biophysics); Retrovirus; Genetic enhancement; Haematopoiesis; Biology; Stem cell; Viral vector; Gene transfer; Gene; Signal transduction; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001376342,0.001000466,0.00137386,0.001179539,0.000391775,0.001234667,0.001137052,0.001768285,0.001367554],"category_scores_gemma":[0.0006910876,0.0003633922,0.0004570742,0.001451178,0.001395538,0.001876049,0.0004843881,0.002134848,0.002456818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008511033,"about_ca_system_score_gemma":0.0006313418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005313437,"about_ca_topic_score_gemma":0.00073262,"domain_scores_codex":[0.9994824,0.0001142333,0.00005089786,0.00007938764,0.0002396714,0.00003339421],"domain_scores_gemma":[0.9994617,0.000323673,0.00005775212,0.00004565263,0.00008824701,0.00002286831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001177192,0.0001591563,0.0002483013,0.009244851,0.000046089,0.0006202045,0.0001728317,0.001000745,0.05813508,0.0193428,0.004201768,0.9067104],"study_design_scores_gemma":[0.00003957062,0.000571774,0.001246759,0.001178123,0.0001279193,0.005843042,0.0001492141,0.0004429659,0.07552035,0.009293178,0.9055231,0.00006397477],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001634098,0.9877816,0.006193909,0.0003975344,0.0003929833,0.00001936495,0.00001157968,0.00004105824,0.003527908],"genre_scores_gemma":[0.00725794,0.9844688,0.004466064,0.0003372849,0.0002751062,0.00002709481,0.00002474117,0.00001378413,0.003129228],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001768285,"threshold_uncertainty_score":0.007278919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0254304856406943,"score_gpt":0.300509504857139,"score_spread":0.2750790192164447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}