{"id":"W2011872467","doi":"10.1016/j.leukres.2005.05.010","title":"5-Aza-2′-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation","year":2005,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Cancer Institute; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Decitabine; Trichostatin A; Cancer research; Chromatin remodeling; Myeloid leukemia; Histone; Chromatin; Acetylation; DNA methylation; Chromatin immunoprecipitation; Epigenetics; Chemistry; Methylation; Histone deacetylase inhibitor; Biology; Histone deacetylase; Molecular biology; Promoter; Gene; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002765993,0.0003768271,0.0004604444,0.0004744077,0.0003169719,0.00006415284,0.0005314884,0.0005915709,0.00004000975],"category_scores_gemma":[0.0007179552,0.0003870479,0.0001447182,0.0005916729,0.0002206095,0.00004538445,0.0005151049,0.0008608177,0.00001163356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001711242,"about_ca_system_score_gemma":0.0007775049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410646,"about_ca_topic_score_gemma":0.0008971101,"domain_scores_codex":[0.9954472,0.0006409294,0.001001123,0.001056574,0.0009699159,0.0008842804],"domain_scores_gemma":[0.9976649,0.00009017679,0.0003415844,0.001082815,0.0005201877,0.0003003218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002992718,0.00009773589,0.0008320467,0.00007378658,0.00005260728,0.0000137138,0.0005030039,0.000928218,0.9917853,0.0001741106,0.0008404583,0.004399732],"study_design_scores_gemma":[0.002150187,0.0005445967,0.000946544,0.0001838931,0.00002951775,0.000006601513,0.0001248524,0.005236987,0.9871148,0.001075194,0.002177402,0.0004093518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931842,0.002865988,0.001968501,0.0003674521,0.00008646487,0.0008108776,0.00003482267,0.00003342435,0.000648249],"genre_scores_gemma":[0.9911861,0.001567853,0.003713596,0.00006570063,0.0003195201,0.0001231495,0.0004628811,0.0001022256,0.002459018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004670441,"threshold_uncertainty_score":0.9998581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03042550730184956,"score_gpt":0.3676844766699895,"score_spread":0.33725896936814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}