{"id":"W2011872467","doi":"10.1016/j.leukres.2005.05.010","title":"5-Aza-2′-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation","year":2005,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Cancer Institute; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Decitabine; Trichostatin A; Cancer research; Chromatin remodeling; Myeloid leukemia; Histone; Chromatin; Acetylation; DNA methylation; Chromatin immunoprecipitation; Epigenetics; Chemistry; Methylation; Histone deacetylase inhibitor; Biology; Histone deacetylase; Molecular biology; Promoter; Gene; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163987,0.0002619634,0.0004832466,0.0002167333,0.0002353877,0.0002529631,0.0003500101,0.0001885586,0.001832079],"category_scores_gemma":[0.0001416059,0.0002104016,0.0001615647,0.0001839676,0.0001638098,0.00008864495,0.0001822213,0.0005704112,0.0004439557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003957728,"about_ca_system_score_gemma":0.00037305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094317,"about_ca_topic_score_gemma":0.005435111,"domain_scores_codex":[0.9999136,0.00001391218,0.00001072079,0.00001168586,0.00001667953,0.00003336347],"domain_scores_gemma":[0.999934,0.00001510184,0.00000964319,0.00001392922,0.000006157532,0.00002115813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008934516,0.00009992613,0.0002041205,0.00008236995,0.0000183966,0.00008447888,0.00002123415,0.000129648,0.9924615,0.0001789064,0.0002853208,0.005540789],"study_design_scores_gemma":[0.0001668116,0.0004475713,0.004729318,0.000005568097,0.00003053855,0.0001990582,0.00001689645,0.000379691,0.988478,0.00004601405,0.00549639,0.000004123527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895812,0.005339555,0.00120189,0.0002404857,0.0001565869,0.00005570849,0.0005913934,0.0001931244,0.002640021],"genre_scores_gemma":[0.9934722,0.001709644,0.001004678,0.0000759367,0.00002289446,0.00004306801,0.0008267351,0.00002518682,0.002819673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094317,"threshold_uncertainty_score":0.006128907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03042550730184956,"score_gpt":0.3676844766699895,"score_spread":0.33725896936814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}