{"id":"W2011899558","doi":"10.1101/gr.164871.113","title":"Systems consequences of amplicon formation in human breast cancer","year":2014,"lang":"en","type":"article","venue":"Genome Research","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Office of International Science and Engineering; National Cancer Institute; New York Genome Center; National Institutes of Health; National Science Foundation","keywords":"Biology; Amplicon; Breast cancer; Locus (genetics); Genetics; Gene; Gene duplication; Carcinogenesis; Cancer; Tumor suppressor gene; Transcriptome; Cancer research; Gene expression; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002820532,0.0001867601,0.0001878105,0.0004907418,0.0002009384,0.0003334889,0.000153251,0.00024602,0.001816644],"category_scores_gemma":[0.0003779617,0.0002113323,0.0001878116,0.0003122884,0.000238346,0.0001323311,0.0004377238,0.0002829773,0.0004695669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856706,"about_ca_system_score_gemma":0.0001977188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006587486,"about_ca_topic_score_gemma":0.001064588,"domain_scores_codex":[0.9996949,0.00005205386,0.00002070941,0.00009261806,0.00008062997,0.00005896799],"domain_scores_gemma":[0.9997359,0.00006987925,0.00008495479,0.0000504644,0.00002768042,0.00003117561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001298788,0.00001197244,0.004485643,0.00002858721,0.00001353688,0.0001353284,0.00004628366,0.0002803392,0.9911493,0.0003613579,0.00003903308,0.003318793],"study_design_scores_gemma":[0.0000105671,0.0003276999,0.106404,0.000007878118,0.00006583271,0.001822047,0.00008545799,0.002288889,0.8838508,0.0005601402,0.004565264,0.00001139662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952928,0.000681587,0.002255621,0.0000466361,0.000005841375,0.00001427297,0.0003898423,0.0000749741,0.001238273],"genre_scores_gemma":[0.9957682,0.0003052448,0.001694964,0.00003041602,0.000003226716,0.00001415374,0.000972446,0.00002558271,0.001185879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001816644,"threshold_uncertainty_score":0.00607723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06750138986666714,"score_gpt":0.3823718321880946,"score_spread":0.3148704423214274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}