{"id":"W2011941471","doi":"10.1038/nrg3539","title":"Emerging patterns of somatic mutations in cancer","year":2013,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":502,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Computational biology; Biology; Massive parallel sequencing; Exome sequencing; Genomics; Exome; DNA sequencing; Germline mutation; Somatic cell; Genome; Genetics; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009921475,0.0006571925,0.001112307,0.00198255,0.0002075035,0.001211801,0.000981682,0.001499997,0.001954909],"category_scores_gemma":[0.001388119,0.0003028827,0.000352853,0.002147784,0.0009989609,0.001465278,0.0009602737,0.001818832,0.000912679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009653548,"about_ca_system_score_gemma":0.001066612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367147,"about_ca_topic_score_gemma":0.003612378,"domain_scores_codex":[0.9996639,0.00004750597,0.00003702621,0.0000753451,0.0001450033,0.00003108543],"domain_scores_gemma":[0.9993662,0.0003408569,0.00006577471,0.00001874584,0.0001627982,0.00004551981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005519435,0.0000194451,0.0005124307,0.004988061,0.00006625021,0.000262976,0.00004694798,0.0004858407,0.002118298,0.005534048,0.02401037,0.9619001],"study_design_scores_gemma":[0.0000217231,0.00005151116,0.002462985,0.002857316,0.0001730238,0.003411792,0.000106683,0.0002648129,0.001129377,0.008940471,0.9805521,0.00002810475],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001257591,0.9981792,0.000335163,0.0005322212,0.0001584394,0.000001802153,0.00002014118,0.00001013053,0.0006371085],"genre_scores_gemma":[0.0009564885,0.9977169,0.0002769747,0.0003918326,0.0002695207,0.000002721249,0.00002405557,0.000001883847,0.0003596545],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00198255,"threshold_uncertainty_score":0.007004201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910067384542327,"score_gpt":0.3680814295234029,"score_spread":0.3389807556779797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}