{"id":"W2011955099","doi":"10.1002/stem.1994","title":"Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Amgen","keywords":"Reprogramming; Biology; Progenitor cell; Myeloid leukemia; Haematopoiesis; Induced pluripotent stem cell; Cancer research; Leukemia; Stem cell; Myeloid; Bone marrow; Immunology; Cell biology; Cell; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188012,0.0002121817,0.000117359,0.000186965,0.0001055218,0.000289119,0.0001311269,0.0001662944,0.001369127],"category_scores_gemma":[0.0001385456,0.00007771673,0.0001453856,0.0001204471,0.0001870852,0.0001169461,0.000298768,0.0002855778,0.00030253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008951461,"about_ca_system_score_gemma":0.0001297361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000846643,"about_ca_topic_score_gemma":0.0001580543,"domain_scores_codex":[0.9998872,0.0000204101,0.00001072711,0.00002844275,0.00004165983,0.00001151402],"domain_scores_gemma":[0.9999413,0.00001393796,0.00001666319,0.00001529458,0.000004828761,0.000007824633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003276171,0.00001978706,0.0008268643,0.00004262126,0.000007660748,0.0001802581,0.00003277864,0.0003686198,0.9826748,0.001368381,0.0001259819,0.01431951],"study_design_scores_gemma":[0.00001132211,0.0001438042,0.003185063,0.00001134691,0.00002764408,0.00198531,0.00003296884,0.001310651,0.9756327,0.0004680281,0.01718526,0.000005927736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9095007,0.00236982,0.07452104,0.0003601129,0.0001117337,0.0001957564,0.001144216,0.000470126,0.01132641],"genre_scores_gemma":[0.9839139,0.001675855,0.01116083,0.0001115263,0.0000200667,0.00005357635,0.0007623156,0.00003134462,0.002270488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369127,"threshold_uncertainty_score":0.00458014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03519519277152021,"score_gpt":0.2417481886757524,"score_spread":0.2065529959042322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}