{"id":"W2011958502","doi":"10.1081/rrs-200035217","title":"Chimeric G Proteins Extend the Range of Insect Cell-Based Functional Assays for Human G Protein-Coupled Receptors","year":2004,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"G protein-coupled receptor; G protein; Sf9; Receptor; Biology; Gq alpha subunit; Cell biology; Gs alpha subunit; Fusion protein; Aequorin; Agonist; Rhodopsin-like receptors; Signal transduction; Biochemistry; Intracellular; Metabotropic receptor; Recombinant DNA; Spodoptera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008037015,0.0002040493,0.0002866501,0.0001124756,0.0002498078,0.00002997786,0.0001375977,0.0001673904,0.0002371618],"category_scores_gemma":[0.00002663646,0.000143139,0.0003337372,0.0001405986,0.0001159035,0.00002102119,0.000008641478,0.0002041078,3.521866e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003129893,"about_ca_system_score_gemma":0.0001622453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002433732,"about_ca_topic_score_gemma":0.000007347132,"domain_scores_codex":[0.9986229,0.00009559547,0.0005454761,0.0002244525,0.0003088906,0.0002026997],"domain_scores_gemma":[0.9989806,0.00002017939,0.0004818064,0.0001183379,0.0003063641,0.00009270455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006092824,0.0001693311,0.00007499228,0.00007653669,0.00007753971,4.959995e-7,0.0001121674,0.002673133,0.9941301,0.0001165827,0.00008454296,0.001875283],"study_design_scores_gemma":[0.002615885,0.002809745,0.0001851576,0.00008868029,0.00008418728,0.00002840807,0.0002280977,0.00005898234,0.9901364,0.000796125,0.002781472,0.0001868148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8078587,0.0007809916,0.1900519,0.0002017234,0.0004915046,0.0005790524,0.000008500531,0.000004893601,0.00002268871],"genre_scores_gemma":[0.9949232,0.0001036326,0.003979017,0.00003485387,0.0007450215,0.00004600439,0.00002442538,0.00003045038,0.0001134268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1870645,"threshold_uncertainty_score":0.5837038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01707394662247274,"score_gpt":0.2287397190868801,"score_spread":0.2116657724644074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}