{"id":"W2011958502","doi":"10.1081/rrs-200035217","title":"Chimeric G Proteins Extend the Range of Insect Cell-Based Functional Assays for Human G Protein-Coupled Receptors","year":2004,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"G protein-coupled receptor; G protein; Sf9; Receptor; Biology; Gq alpha subunit; Cell biology; Gs alpha subunit; Fusion protein; Aequorin; Agonist; Rhodopsin-like receptors; Signal transduction; Biochemistry; Intracellular; Metabotropic receptor; Recombinant DNA; Spodoptera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001172315,0.001091415,0.0008040793,0.0006019518,0.0002859781,0.0008499277,0.0008247541,0.001179392,0.002723585],"category_scores_gemma":[0.0006163624,0.0005237148,0.0008558526,0.0005484918,0.0004432129,0.0004896923,0.0006654305,0.001747896,0.001554386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005448911,"about_ca_system_score_gemma":0.0002897321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008019521,"about_ca_topic_score_gemma":0.001626763,"domain_scores_codex":[0.998755,0.0003696551,0.0001608615,0.0002641345,0.0003089739,0.0001413933],"domain_scores_gemma":[0.9995924,0.0001653244,0.0000468549,0.00007828803,0.00006738212,0.00004986599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005878393,0.00002450785,0.0001275825,0.00005863008,0.0000100789,0.00002688772,0.00001500135,0.00005502867,0.9983183,0.0001350616,0.00008348518,0.001086568],"study_design_scores_gemma":[0.0001031292,0.0006757809,0.003836696,0.00003282753,0.00009210459,0.0009889794,0.00004549144,0.002568967,0.9773033,0.000317555,0.01400178,0.00003325166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8193278,0.01450402,0.1497464,0.00127001,0.0003552047,0.0007756169,0.003821742,0.001979219,0.008219972],"genre_scores_gemma":[0.7677995,0.01025412,0.2057274,0.001244278,0.0001021484,0.0007187843,0.006652295,0.0003289046,0.007172571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002723585,"threshold_uncertainty_score":0.009111285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01707394662247274,"score_gpt":0.2287397190868801,"score_spread":0.2116657724644074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}