{"id":"W2011964198","doi":"10.1089/adt.2007.062","title":"Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening","year":2007,"lang":"en","type":"review","venue":"Assay and Drug Development Technologies","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"G protein-coupled receptor; Guanine; Function (biology); Computational biology; Throughput; Nucleotide; Biology; Receptor; Chemistry; Genetics; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007543482,0.0003887347,0.0007384812,0.0002038183,0.0002996472,0.00003882535,0.0002228128,0.0005155148,0.000008858935],"category_scores_gemma":[0.0002122025,0.0003338451,0.0001144448,0.0002084174,0.0001354047,0.00001260107,0.0003058297,0.0001886067,0.000001072349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002673907,"about_ca_system_score_gemma":0.0001117495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005027949,"about_ca_topic_score_gemma":0.000005003857,"domain_scores_codex":[0.9982563,0.00003491942,0.0006466315,0.0006213492,0.0001089535,0.0003318384],"domain_scores_gemma":[0.9989956,0.00008208135,0.0004896364,0.0002752054,0.0001200781,0.00003738379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001703903,0.00001802502,0.00002521765,0.001560627,0.000216077,1.908908e-7,0.00002823944,4.491875e-7,0.04336211,0.002948907,0.000157708,0.9516654],"study_design_scores_gemma":[0.0005032186,0.0001677398,0.00001408261,0.003148431,0.0002071592,0.000008217027,0.0007281356,0.000003882968,0.1047299,0.0008420102,0.8889312,0.0007160744],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01095522,0.9156648,0.07127836,0.0001104894,0.000154332,0.001586739,0.00004317332,0.000166,0.00004089142],"genre_scores_gemma":[0.01422744,0.9054596,0.0786969,0.00001056798,0.00006779123,0.0005031117,0.0006134494,0.00006488025,0.0003562714],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9509493,"threshold_uncertainty_score":0.9999114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03043812253801149,"score_gpt":0.3085874231524183,"score_spread":0.2781493006144068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}