{"id":"W2011964198","doi":"10.1089/adt.2007.062","title":"Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening","year":2007,"lang":"en","type":"review","venue":"Assay and Drug Development Technologies","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"G protein-coupled receptor; Guanine; Function (biology); Computational biology; Throughput; Nucleotide; Biology; Receptor; Chemistry; Genetics; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006834978,0.001420324,0.003418932,0.001822368,0.000451104,0.003577187,0.002887717,0.002014572,0.003082099],"category_scores_gemma":[0.007426095,0.0008422522,0.00114235,0.002759717,0.002659894,0.004121564,0.001718081,0.003650268,0.002292063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002228335,"about_ca_system_score_gemma":0.001284099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009879171,"about_ca_topic_score_gemma":0.0008171951,"domain_scores_codex":[0.9944666,0.002281905,0.0002278376,0.0007566811,0.002005064,0.0002619141],"domain_scores_gemma":[0.9954551,0.003135906,0.0002701255,0.0004117736,0.0005789106,0.0001482786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001030497,0.000847985,0.004306386,0.006847367,0.000439881,0.0008844984,0.000381955,0.02361852,0.2089246,0.2070579,0.02816888,0.5174914],"study_design_scores_gemma":[0.0003322588,0.003782422,0.007656013,0.001587253,0.0006286719,0.005297241,0.0005805613,0.1271899,0.2666928,0.2049698,0.3807104,0.0005727166],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.02735362,0.3011092,0.6308759,0.009893587,0.001024975,0.000594785,0.002271622,0.002994563,0.02388178],"genre_scores_gemma":[0.2010275,0.4184834,0.3555901,0.005794986,0.001389386,0.002163703,0.003875202,0.0003779296,0.01129781],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006834978,"threshold_uncertainty_score":0.0361473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03043812253801149,"score_gpt":0.3085874231524183,"score_spread":0.2781493006144068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}