{"id":"W2011967594","doi":"10.1021/acs.analchem.5b00220","title":"DNAzyme Hybridization, Cleavage, Degradation, and Sensing in Undiluted Human Blood Serum","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"China Scholarship Council; University of Waterloo; Central South University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; Deoxyribozyme; Cleavage (geology); Degradation (telecommunications); Environmental chemistry; Chromatography; Detection limit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007999624,0.0005259439,0.0003994796,0.0002298672,0.0001084312,0.0003122509,0.0003197744,0.0005317884,0.0002660237],"category_scores_gemma":[0.001099257,0.0002940485,0.000245964,0.0003088361,0.0003135309,0.0002391233,0.0001963385,0.0004747022,0.000251448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625117,"about_ca_system_score_gemma":0.0003095681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583192,"about_ca_topic_score_gemma":0.001420498,"domain_scores_codex":[0.9991964,0.0002395429,0.00005680693,0.0002020704,0.0002305077,0.00007476656],"domain_scores_gemma":[0.9996418,0.0001452111,0.00006948009,0.00002196935,0.00008176635,0.00003979027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004757507,0.00000808701,0.0004058235,0.00005366064,0.000005838791,0.00003338496,0.00004477127,0.0001035392,0.9971399,0.00002642233,0.00001261269,0.002118423],"study_design_scores_gemma":[0.000004384935,0.0001764789,0.001492493,0.000006401917,0.00001035454,0.0001878396,0.00003002214,0.001334995,0.9961288,0.00003291152,0.0005896618,0.000005680521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534431,0.01062632,0.03443762,0.0001658857,0.00003512046,0.00006795584,0.0001357975,0.000132478,0.0009556577],"genre_scores_gemma":[0.9560854,0.006686774,0.03359465,0.0001816998,0.0000233896,0.0001132436,0.0002875112,0.00003569697,0.002991664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583192,"threshold_uncertainty_score":0.004230678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675015503292793,"score_gpt":0.2828699716662098,"score_spread":0.2661198166332818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}