{"id":"W2011967594","doi":"10.1021/acs.analchem.5b00220","title":"DNAzyme Hybridization, Cleavage, Degradation, and Sensing in Undiluted Human Blood Serum","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"China Scholarship Council; University of Waterloo; Central South University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; Deoxyribozyme; Cleavage (geology); Degradation (telecommunications); Environmental chemistry; Chromatography; Detection limit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001910238,0.0001529174,0.0001702637,0.00003528291,0.00005602537,0.00003422851,0.00007960966,0.0001618432,0.000001986805],"category_scores_gemma":[0.0002134496,0.0001491846,0.00004534426,0.0002109041,0.0001307233,0.000006107182,0.00008344216,0.0001122133,9.85502e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002073711,"about_ca_system_score_gemma":0.00004614393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002071494,"about_ca_topic_score_gemma":0.00003097725,"domain_scores_codex":[0.9989996,0.00002811443,0.0002516573,0.0003769221,0.0001341182,0.000209583],"domain_scores_gemma":[0.9993933,0.000008503653,0.000065531,0.0002614535,0.0001235892,0.0001476216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002763044,0.0001082432,0.02076165,0.00002955198,0.00008470959,0.00003603056,0.00001394191,0.00001464912,0.975633,0.0000741964,0.002321644,0.0008947779],"study_design_scores_gemma":[0.0004967976,0.00004648571,0.001423666,0.00002213499,0.00007219108,0.00005653452,0.00008402508,0.0006819962,0.9947886,0.0004116646,0.001669502,0.0002463361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99608,0.0001109726,0.001152859,0.0002469003,0.000008321552,0.0000477926,0.000008046428,0.00003968236,0.002305407],"genre_scores_gemma":[0.9966851,0.00003470446,0.001628456,0.0001503696,0.0001146621,7.764036e-7,0.0002117209,0.00001600898,0.00115819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01933799,"threshold_uncertainty_score":0.6083571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675015503292793,"score_gpt":0.2828699716662098,"score_spread":0.2661198166332818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}