{"id":"W2012031383","doi":"10.1371/journal.pone.0053964","title":"MERTK Interactions with SH2-Domain Proteins in the Retinal Pigment Epithelium","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Eye Institute; University of Michigan; Karolinska Institutet; Ontario Genomics Institute; Wellcome Trust; GlaxoSmithKline; Ontario Innovation Trust; Stiftelsen för Strategisk Forskning; National Institutes of Health; Ontario Genomics; Genome Canada; Knut och Alice Wallenbergs Stiftelse; Research to Prevent Blindness","keywords":"MERTK; GRB2; SH2 domain; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Autophosphorylation; Biology; Retinal pigment epithelium; SH3 domain; Tyrosine phosphorylation; Receptor tyrosine kinase; Fusion protein; Phosphotyrosine-binding domain; Signal transduction; Phosphorylation; Biochemistry; Chemistry; Protein kinase A; Retinal; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072723,0.00009459187,0.00007874445,0.00002816367,0.00005495618,0.00002993724,0.0001463566,0.00003309983,0.0001215609],"category_scores_gemma":[0.00002477177,0.00006053298,0.00002253708,0.00007802636,0.00004533484,0.000005173757,0.0000359871,0.0000914651,0.00007193217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009696335,"about_ca_system_score_gemma":0.00003218395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006456266,"about_ca_topic_score_gemma":0.0001533596,"domain_scores_codex":[0.999325,0.00005490153,0.0001179038,0.0001718646,0.0001645205,0.0001657442],"domain_scores_gemma":[0.9996852,0.000008523875,0.00003952509,0.0001909501,0.00004562011,0.00003023188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001886912,0.001522706,0.03423311,0.00004663822,0.0001511487,0.000005625794,0.0007153275,0.000003319231,0.9599774,0.0002162738,0.002302923,0.0006368491],"study_design_scores_gemma":[0.003349374,0.002652403,0.2408574,0.000553423,0.0001257856,0.00004056167,0.006304907,0.0001179823,0.7151251,0.002452013,0.02725543,0.001165685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856727,0.00007642848,0.0002067006,0.003439166,0.0000104568,0.0005744979,0.000001538754,0.000006336367,0.01001223],"genre_scores_gemma":[0.9936256,0.00005035177,0.004124144,0.0004574251,0.00005462694,0.0004016115,0.00004104312,0.00001081929,0.001234379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2448523,"threshold_uncertainty_score":0.2468463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538889764090028,"score_gpt":0.207568994127588,"score_spread":0.1921800964866877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}