{"id":"W2012031383","doi":"10.1371/journal.pone.0053964","title":"MERTK Interactions with SH2-Domain Proteins in the Retinal Pigment Epithelium","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Eye Institute; University of Michigan; Karolinska Institutet; Ontario Genomics Institute; Wellcome Trust; GlaxoSmithKline; Ontario Innovation Trust; Stiftelsen för Strategisk Forskning; National Institutes of Health; Ontario Genomics; Genome Canada; Knut och Alice Wallenbergs Stiftelse; Research to Prevent Blindness","keywords":"MERTK; GRB2; SH2 domain; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Autophosphorylation; Biology; Retinal pigment epithelium; SH3 domain; Tyrosine phosphorylation; Receptor tyrosine kinase; Fusion protein; Phosphotyrosine-binding domain; Signal transduction; Phosphorylation; Biochemistry; Chemistry; Protein kinase A; Retinal; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770268,0.0002459989,0.0002734037,0.0001509511,0.0003313254,0.0004657579,0.0001771496,0.0005387751,0.001078724],"category_scores_gemma":[0.0001444896,0.0001714965,0.0004798689,0.0001885273,0.0001339106,0.0004125827,0.0003114654,0.0003993398,0.0005962802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005961708,"about_ca_system_score_gemma":0.0001679659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170343,"about_ca_topic_score_gemma":0.001223081,"domain_scores_codex":[0.9997541,0.00003121176,0.00001791616,0.00006323429,0.00008157466,0.00005201952],"domain_scores_gemma":[0.9999378,0.000007998849,0.00001783737,0.000007188278,0.00001388874,0.00001523835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295718,0.00001438719,0.0006157642,0.00005503205,0.00001198906,0.0001282303,0.00002777992,0.0000656144,0.9982882,0.00005600951,0.00004269032,0.0005646875],"study_design_scores_gemma":[0.00002078406,0.0001786918,0.03411702,0.00001972543,0.0000401488,0.001112027,0.0001806046,0.003401682,0.9558545,0.00008609152,0.004971901,0.00001678559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953479,0.002773314,0.0009391746,0.00008668778,0.00001868741,0.000007742196,0.0001456683,0.00002081354,0.0006601352],"genre_scores_gemma":[0.9945294,0.001016895,0.001121631,0.00008176672,0.0000057608,0.00001198931,0.000407056,0.00001100998,0.00281441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170343,"threshold_uncertainty_score":0.004325509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538889764090028,"score_gpt":0.207568994127588,"score_spread":0.1921800964866877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}