{"id":"W2012042113","doi":"10.1038/onc.2011.80","title":"Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institute on Drug Abuse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Carcinogenesis; Epigenetics; Suppressor; Gene silencing; Gene; Tumor suppressor gene; Cancer research; Cancer; Somatic cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802451,0.0002556918,0.0003908495,0.0002807161,0.0001679465,0.0003097727,0.0003999218,0.0003854,0.001843776],"category_scores_gemma":[0.0001070904,0.0001534735,0.0002499641,0.0001710502,0.0002508077,0.0002208703,0.0001796528,0.0008399513,0.0004186236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291373,"about_ca_system_score_gemma":0.0003054118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003486621,"about_ca_topic_score_gemma":0.001370765,"domain_scores_codex":[0.9999249,0.00001273159,0.000004368803,0.00001498532,0.000020974,0.00002194575],"domain_scores_gemma":[0.9999707,0.000005509649,0.000008699364,0.000005704682,0.000003185294,0.000006135717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002724392,0.0001920275,0.0001492095,0.00009539433,0.00001618775,0.00008859294,0.00001847604,0.0002360278,0.9790797,0.001557704,0.0005840723,0.01771014],"study_design_scores_gemma":[0.0002844915,0.001471051,0.00209576,0.00001192547,0.00004294082,0.0006129226,0.00002825365,0.001313184,0.9798293,0.0002663835,0.01403146,0.00001213391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581658,0.009382738,0.01842891,0.00196477,0.00031652,0.0002412704,0.0006589676,0.0007069836,0.01013399],"genre_scores_gemma":[0.9903958,0.002621217,0.003503402,0.0002030244,0.00002917859,0.00006075185,0.0002653081,0.00002408728,0.002897235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001843776,"threshold_uncertainty_score":0.006168067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04730117009840405,"score_gpt":0.2725594281197073,"score_spread":0.2252582580213033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}