{"id":"W2012042113","doi":"10.1038/onc.2011.80","title":"Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institute on Drug Abuse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Carcinogenesis; Epigenetics; Suppressor; Gene silencing; Gene; Tumor suppressor gene; Cancer research; Cancer; Somatic cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000909608,0.0001136049,0.0001533046,0.00001397281,0.00003326206,0.000001693866,0.0001548401,0.00008429948,0.00008760026],"category_scores_gemma":[0.00001529773,0.00007724562,0.0001120587,0.00007784096,0.00008846511,0.000001381096,0.00005114901,0.00003609015,0.000001054515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002957436,"about_ca_system_score_gemma":0.0002276196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000330292,"about_ca_topic_score_gemma":0.00004808689,"domain_scores_codex":[0.9992813,0.00003498491,0.0002197613,0.0001915822,0.0001085258,0.0001638588],"domain_scores_gemma":[0.9994619,0.00000363856,0.0001572781,0.0002585483,0.00008419614,0.00003439795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007516446,0.0001668621,0.0003529268,0.00002593117,0.00007780432,5.218391e-7,0.0001146571,0.0003657798,0.9951387,0.0000118486,0.00002769258,0.003642129],"study_design_scores_gemma":[0.0007143231,0.0005222165,0.0008627717,0.00002953054,0.00005597484,0.000003117313,0.00007588197,0.0002478865,0.9971425,0.00002496133,0.0002322758,0.00008856365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961756,0.001488563,0.0007475257,0.00001150269,0.00007893611,0.0002769818,0.00003957693,0.000004683697,0.001176588],"genre_scores_gemma":[0.9975995,0.000191075,0.001699093,0.00003243388,0.00006525132,0.00002833072,0.000006907918,0.0000109098,0.0003664974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003553566,"threshold_uncertainty_score":0.3149985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04730117009840405,"score_gpt":0.2725594281197073,"score_spread":0.2252582580213033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}