{"id":"W2012053477","doi":"10.1371/journal.pone.0015753","title":"A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Diphtheria toxin; Pseudomonas exotoxin; Biology; Mutant; Microbiology; Vibrio cholerae; Exotoxin; Elongation factor; ADP-ribosylation; Toxin; Pseudomonas aeruginosa; Biochemistry; Genetics; Bacteria; Enzyme; RNA; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108573,0.0008379395,0.0004337479,0.0002848184,0.0002237338,0.0004056413,0.0004874969,0.000518078,0.001187618],"category_scores_gemma":[0.0001318692,0.0003041501,0.0003858169,0.0001782783,0.0003955953,0.0002267422,0.0003494195,0.0008919346,0.0004756303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004649198,"about_ca_system_score_gemma":0.0003991069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036916,"about_ca_topic_score_gemma":0.001489785,"domain_scores_codex":[0.9996518,0.00004042606,0.00004254041,0.00008554779,0.000107747,0.00007194097],"domain_scores_gemma":[0.9997813,0.00005425596,0.00005496791,0.00003798992,0.00001952624,0.00005196024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001340656,0.00001049974,0.00002200006,0.00001130537,0.000001896667,0.00001770196,0.000004854588,0.00001626633,0.999633,0.00004934022,0.000008784733,0.0002109408],"study_design_scores_gemma":[0.00001023207,0.0001339382,0.0004765569,0.00000251913,0.0000117309,0.0001742373,0.00001010398,0.0004016398,0.9967105,0.00001371182,0.002050671,0.000004048254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797116,0.001768612,0.01355708,0.0002946575,0.0001419256,0.0001469957,0.0007644367,0.0002632878,0.003351527],"genre_scores_gemma":[0.9842221,0.0008653149,0.008442692,0.0001161251,0.00001614784,0.00007800225,0.0007454289,0.00006821928,0.005445902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187618,"threshold_uncertainty_score":0.003973007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02914469693439334,"score_gpt":0.2226279892112444,"score_spread":0.1934832922768511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}