{"id":"W2012110426","doi":"10.1053/j.gastro.2012.09.031","title":"Challenges to the Design, Execution, and Analysis of Randomized Controlled Trials for Inflammatory Bowel Disease","year":2012,"lang":"en","type":"review","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Robarts Clinical Trials; Western University","funders":"Janssen Pharmaceuticals; Genentech; Tillotts Pharma; Vifor Pharma; Ferring Pharmaceuticals; Zalicus; Optimer Pharmaceuticals; Otsuka America; UCB; Schering-Plough; Boehringer Ingelheim; Takeda Pharmaceutical Company; Novartis; Celgene; Novo Nordisk; Johnson and Johnson; Teva Pharmaceutical Industries; Gilead Sciences; Procter and Gamble; Roche; Orexigen Therapeutics; Merck; GlaxoSmithKline; Pfizer; Shire; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Dr. Falk Pharma; Abbott Laboratories","keywords":"Inflammatory bowel disease; Medicine; Randomized controlled trial; Disease; Intensive care medicine; Inflammatory Bowel Diseases; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4814343,0.002565561,0.02280137,0.003550393,0.001806171,0.01439976,0.01166904,0.00880087,0.005020402],"category_scores_gemma":[0.6149323,0.002331909,0.007843775,0.004261471,0.01103955,0.00939832,0.00564211,0.02178054,0.00198782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006899129,"about_ca_system_score_gemma":0.03277724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003544091,"about_ca_topic_score_gemma":0.00461591,"domain_scores_codex":[0.4705687,0.4501099,0.03969526,0.01044382,0.02732984,0.001852645],"domain_scores_gemma":[0.12186,0.8352713,0.01109015,0.01280502,0.01678933,0.002184351],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003326924,0.0003040985,0.0009390174,0.04737129,0.005215624,0.0001341068,0.0004961967,0.003552759,0.0004434281,0.05785251,0.03678142,0.8435827],"study_design_scores_gemma":[0.01587954,0.003318801,0.004202046,0.1393047,0.01119135,0.000831981,0.0007495831,0.01085667,0.001516879,0.4562969,0.3552671,0.0005844511],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006854489,0.8362855,0.06748198,0.08139306,0.008627562,0.002426855,0.0006568014,0.0003342233,0.002108642],"genre_scores_gemma":[0.03746511,0.4487412,0.4117731,0.06511179,0.01978116,0.0149321,0.0007234883,0.0004680085,0.001004182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5185657,"threshold_uncertainty_score":0.6394838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05940023155815793,"score_gpt":0.3238657225901835,"score_spread":0.2644654910320255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}