{"id":"W2012141576","doi":"10.1136/jmg.2009.066944","title":"Apoptosis and cancer: mutations within caspase genes","year":2009,"lang":"en","type":"review","venue":"Journal of Medical Genetics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":708,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba; Shared Health; Research Manitoba","funders":"Canadian Institutes of Health Research; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Canadian Lung Association; Manitoba Health Research Council","keywords":"XIAP; Caspase; Programmed cell death; Inhibitor of apoptosis; Pyroptosis; Apoptosis; Biology; Proteases; Carcinogenesis; Cancer research; Cancer; Cancer cell; Survivin; Intrinsic apoptosis; Cell biology; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460571,0.0008063267,0.0009155453,0.00159389,0.0002434398,0.0005741633,0.000580784,0.0008510493,0.002556266],"category_scores_gemma":[0.0003394403,0.0001743037,0.0002684677,0.00191758,0.0004510579,0.0008152631,0.0004954321,0.001103287,0.002375298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005773494,"about_ca_system_score_gemma":0.0005397676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000656219,"about_ca_topic_score_gemma":0.0007932074,"domain_scores_codex":[0.9998356,0.00002146082,0.00001985317,0.00003799213,0.00006850868,0.00001643776],"domain_scores_gemma":[0.9998819,0.00004282458,0.00002168579,0.000006750208,0.00003375581,0.0000130939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006634327,0.00004527555,0.0004009939,0.004947369,0.00003870407,0.0007454215,0.00005007629,0.0002708103,0.004590769,0.003385385,0.02471575,0.9607431],"study_design_scores_gemma":[0.00002376054,0.00008418848,0.00181725,0.001130315,0.0000520871,0.009972405,0.00005693295,0.00008733886,0.002128713,0.002935888,0.9816946,0.00001662354],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003426298,0.9966383,0.0003662778,0.0002450849,0.0002198367,0.000005656374,0.00001746473,0.00001828322,0.002146421],"genre_scores_gemma":[0.002560693,0.9946373,0.0003916,0.0002210058,0.0002379225,0.000008302182,0.00005158436,0.000002804525,0.001888774],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002556266,"threshold_uncertainty_score":0.008551538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979151527133992,"score_gpt":0.3492372679801889,"score_spread":0.319445752708849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}