{"id":"W2012141576","doi":"10.1136/jmg.2009.066944","title":"Apoptosis and cancer: mutations within caspase genes","year":2009,"lang":"en","type":"review","venue":"Journal of Medical Genetics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":708,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba; Shared Health; Research Manitoba","funders":"Canadian Institutes of Health Research; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Canadian Lung Association; Manitoba Health Research Council","keywords":"XIAP; Caspase; Programmed cell death; Inhibitor of apoptosis; Pyroptosis; Apoptosis; Biology; Proteases; Carcinogenesis; Cancer research; Cancer; Cancer cell; Survivin; Intrinsic apoptosis; Cell biology; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004526505,0.0002154241,0.0006304518,0.00009730845,0.00005424565,0.00002879029,0.0002435187,0.0006145533,0.00003755093],"category_scores_gemma":[0.00009362189,0.0001531977,0.0002560397,0.0000902789,0.00007427618,0.000001707395,0.00006967111,0.0002840335,0.000001056186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001978349,"about_ca_system_score_gemma":0.0006895722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004247347,"about_ca_topic_score_gemma":0.000007707585,"domain_scores_codex":[0.9983239,0.0001012576,0.0007139075,0.0001834691,0.0005307297,0.0001467022],"domain_scores_gemma":[0.9987714,0.00002245046,0.0006220964,0.0001582876,0.0001300675,0.0002956839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000417514,0.00003246561,0.000001590732,0.0006263669,0.0001290866,0.00001564163,0.0000154791,0.00002900824,0.0003056685,0.000018173,0.0005424146,0.9982799],"study_design_scores_gemma":[0.0002776592,0.0003070469,0.000002962709,0.002015992,0.0007512593,0.000566836,0.00001556854,0.00006283764,0.0008550853,0.00006136367,0.9948925,0.0001909063],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001403341,0.9967318,0.001008084,0.0001525106,0.0005415771,0.0001295942,0.0000135457,0.000002017727,0.00001752869],"genre_scores_gemma":[0.0001041833,0.9965711,0.001664909,0.00009287625,0.001320681,0.000004751124,0.00004300332,0.00002573687,0.0001728035],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.998089,"threshold_uncertainty_score":0.6247221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979151527133992,"score_gpt":0.3492372679801889,"score_spread":0.319445752708849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}