{"id":"W2012192443","doi":"10.1007/s11095-006-0282-x","title":"A New Polymer–Lipid Hybrid Nanoparticle System Increases Cytotoxicity of Doxorubicin Against Multidrug-Resistant Human Breast Cancer Cells","year":2006,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"Cytotoxicity; Doxorubicin; Solid lipid nanoparticle; Pharmacology; Chemistry; Doxorubicin Hydrochloride; Trypan blue; Multiple drug resistance; Drug delivery; In vitro; Biochemistry; Chemotherapy; Medicine; Surgery; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001928467,0.0003245584,0.0002965044,0.0003015501,0.0002031434,0.0003532985,0.000218503,0.0003832457,0.001634409],"category_scores_gemma":[0.0001925059,0.0002086908,0.0001978623,0.0001458438,0.0002392658,0.0004378112,0.0003023487,0.0004716606,0.000428065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604347,"about_ca_system_score_gemma":0.0002501042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004960516,"about_ca_topic_score_gemma":0.00077639,"domain_scores_codex":[0.999909,0.00001832149,0.000007610544,0.00002931622,0.00001758336,0.00001808255],"domain_scores_gemma":[0.999899,0.00002955022,0.00001860202,0.000008392282,0.00001418234,0.00003019066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001500587,0.00003394777,0.0000549312,0.00003509845,0.000007320396,0.00003514514,0.00001411125,0.0000637534,0.9974419,0.00009993593,0.00004589569,0.002017862],"study_design_scores_gemma":[0.00005552762,0.0003761957,0.0005089786,0.000003783671,0.0000326782,0.0001285437,0.000006220348,0.000684829,0.995915,0.00002473606,0.002256549,0.00000701533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883049,0.001293251,0.00800893,0.0002073122,0.00006802132,0.00006080435,0.0001022946,0.0002460262,0.001708603],"genre_scores_gemma":[0.9909672,0.0005058708,0.005437537,0.0000986,0.00002541327,0.00003731745,0.0001631412,0.00005123283,0.00271373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634409,"threshold_uncertainty_score":0.005467653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05532899483376065,"score_gpt":0.3736930447319792,"score_spread":0.3183640498982186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}