{"id":"W2012197995","doi":"10.1074/jbc.m113.505099","title":"CYP82Y1 Is N-Methylcanadine 1-Hydroxylase, a Key Noscapine Biosynthetic Enzyme in Opium Poppy","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Genome Alberta; Government of Alberta; Genome Canada","keywords":"Noscapine; Opium Poppy; Benzylisoquinoline; Poppy; Alkaloid; Cytochrome P450; Metabolite; Chemistry; Hydroxylation; Enzyme; Biochemistry; Stereochemistry; Biology; Biosynthesis; Papaver; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004179187,0.0001862899,0.0005428735,0.0001043261,0.00002780735,0.00002497274,0.0002485742,0.0002589948,0.005797897],"category_scores_gemma":[0.0005542817,0.0001169134,0.0002100477,0.0003285187,0.000152121,0.00007091529,0.00008591783,0.000773037,0.00009064158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157556,"about_ca_system_score_gemma":0.0001463561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001430928,"about_ca_topic_score_gemma":0.000003897404,"domain_scores_codex":[0.9983864,0.00004850212,0.0006084276,0.0002140018,0.0003187772,0.0004238677],"domain_scores_gemma":[0.9987782,0.0001401999,0.0001780597,0.0002200159,0.0002312806,0.0004523016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001364182,0.000324926,0.008075645,0.00008744687,0.00005530204,0.0003612642,0.00002823402,0.000001467009,0.9782587,0.00000367909,0.008923137,0.003743799],"study_design_scores_gemma":[0.00234663,0.0008405869,0.01719684,0.0002973976,0.00002842084,0.001571361,0.000189289,0.0002213464,0.9489769,0.0003429184,0.0277392,0.0002490578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860897,0.001005915,0.00001917604,0.0080819,0.00004416816,0.0001255737,0.000008274309,0.00001114027,0.004614149],"genre_scores_gemma":[0.9957818,0.0005497884,0.0005895651,0.0008121232,0.0004323878,0.000006570987,0.000007641564,0.00001263287,0.001807479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02928173,"threshold_uncertainty_score":0.9951109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02807848816143893,"score_gpt":0.2897437913991382,"score_spread":0.2616653032376993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}