{"id":"W2012213919","doi":"10.1126/science.1248357","title":"Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Histone H3; Biology; Histone methylation; Histone methyltransferase; Heterochromatin protein 1; Histone; EZH2; Histone H2A; Histone code; Heterochromatin; Chromatin; PRC2; Genetics; Cell biology; Gene; DNA methylation; Gene expression; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001014134,0.0001521018,0.0001440084,0.0001044272,0.000153277,0.0002736627,0.0001994395,0.00017502,0.0008160298],"category_scores_gemma":[0.0001108031,0.000128377,0.0001668224,0.00007922382,0.0002192783,0.0001576479,0.0001690948,0.0002508402,0.0003508442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004015258,"about_ca_system_score_gemma":0.0001540032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009900617,"about_ca_topic_score_gemma":0.001679041,"domain_scores_codex":[0.9999365,0.000006994738,0.000002647288,0.00002225689,0.00001249811,0.00001911399],"domain_scores_gemma":[0.999918,0.00001267984,0.00002696673,0.00001015224,0.00001034843,0.00002181909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009168274,0.000005381412,0.0008650313,0.000009681693,0.000003554638,0.00001543061,0.00000993326,0.00005037862,0.9974808,0.00008659148,0.00003702379,0.001344428],"study_design_scores_gemma":[0.00002984045,0.0001378844,0.1014372,0.000004811018,0.00001839904,0.0002458097,0.00005337614,0.002887268,0.8933318,0.0002711478,0.00157422,0.000008277831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955319,0.001167139,0.001689726,0.00005275684,0.00001175302,0.000007512572,0.0001210358,0.00009715664,0.001320991],"genre_scores_gemma":[0.9984508,0.0002004498,0.000323815,0.00001521128,0.000003787705,0.000003492724,0.00008511409,0.00001078569,0.0009064847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009900617,"threshold_uncertainty_score":0.002913296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750066139614873,"score_gpt":0.2963620617824062,"score_spread":0.2788614003862575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}