{"id":"W2012213919","doi":"10.1126/science.1248357","title":"Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Histone H3; Biology; Histone methylation; Histone methyltransferase; Heterochromatin protein 1; Histone; EZH2; Histone H2A; Histone code; Heterochromatin; Chromatin; PRC2; Genetics; Cell biology; Gene; DNA methylation; Gene expression; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001443848,0.00006026786,0.0001002407,0.00002771422,0.0001915508,0.00002122934,0.0003837185,0.00004892794,0.00003029809],"category_scores_gemma":[0.0007066206,0.00002415616,0.00002687588,0.0007409071,0.0003874587,0.0001179559,0.00007960619,0.00006173743,0.00001948313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003675645,"about_ca_system_score_gemma":0.00001973356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008622657,"about_ca_topic_score_gemma":0.00005132554,"domain_scores_codex":[0.9988699,0.0001201525,0.0001456644,0.0003721126,0.0002850672,0.0002071019],"domain_scores_gemma":[0.9993896,0.0001532955,0.0001072927,0.0001240228,0.0001689313,0.00005687458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006712299,0.00001616515,0.0008091663,0.000001785079,0.000001412584,2.033018e-7,0.00003480076,0.000004100637,0.9781579,0.0005011025,0.00002756628,0.02043903],"study_design_scores_gemma":[0.00003695408,0.0001909857,0.3056565,0.000007885505,0.000001911942,0.000009630694,0.00001176326,0.001925042,0.6896652,0.001837642,0.0005929314,0.00006359362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978585,0.00003796735,0.0002351669,0.0005175359,0.00003656343,0.0001276305,0.000006048395,0.00002681538,0.001153796],"genre_scores_gemma":[0.9991933,0.000004632469,0.0005868385,0.0000457214,0.0000290591,0.000007887714,0.00001783386,3.257583e-7,0.0001144263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3048473,"threshold_uncertainty_score":0.1473273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750066139614873,"score_gpt":0.2963620617824062,"score_spread":0.2788614003862575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}