{"id":"W2012215212","doi":"10.1074/jbc.m406990200","title":"Myristoylation, a Protruding Loop, and Structural Plasticity Are Essential Features of a Nonenveloped Virus Fusion Peptide Motif","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts","keywords":"Ectodomain; Myristoylation; Lipid bilayer fusion; Peptide; Circular dichroism; Chemistry; Transmembrane domain; Transmembrane protein; Peptide sequence; Biophysics; Biochemistry; Biology; Amino acid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740627,0.00016793,0.0002780172,0.00003107128,0.00008121559,0.00002004455,0.000275727,0.0002522596,0.00004076535],"category_scores_gemma":[0.0005144002,0.0001199305,0.0001233582,0.00008696901,0.0002296906,0.000006946566,0.0001726247,0.0002817669,5.022337e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003487682,"about_ca_system_score_gemma":0.0001178791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005876942,"about_ca_topic_score_gemma":0.000008564394,"domain_scores_codex":[0.9988883,0.00004918117,0.000393041,0.0002265722,0.0002332707,0.000209618],"domain_scores_gemma":[0.9990045,0.00002511596,0.0004231142,0.0001537866,0.0002604973,0.0001329662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002513288,0.00006031801,0.003447064,0.00005237851,0.00006398271,0.00001741635,0.00001963048,0.000258363,0.9931266,0.00000191591,0.00008027739,0.0003587164],"study_design_scores_gemma":[0.001199928,0.0009681867,0.02106953,0.00005988667,0.00001445151,0.0001968413,0.00006155699,0.00000805083,0.975921,0.0003115066,0.00005436513,0.0001346501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986308,0.0008238396,0.000189254,0.000115019,0.00003098041,0.0001060569,0.00002118921,0.000004432922,0.00007844841],"genre_scores_gemma":[0.9985764,0.0002992937,0.0007023557,0.00003439169,0.0003110402,0.000002831103,0.00001646432,0.00001032424,0.00004691578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01762247,"threshold_uncertainty_score":0.4890626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762347178103267,"score_gpt":0.286033958519835,"score_spread":0.2684104867388023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}