{"id":"W2012232878","doi":"10.1038/cddis.2012.121","title":"An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity","year":2012,"lang":"en","type":"review","venue":"Cell Death and Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Huntingtin; Cell biology; Mutant; In vitro; Toxicity; Biology; Chemistry; Computational biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004976374,0.001067155,0.00137506,0.001318995,0.0002421028,0.000839302,0.000945071,0.001273928,0.001579467],"category_scores_gemma":[0.0002734668,0.0003102719,0.0004331981,0.001051354,0.0006169704,0.001304424,0.0005508366,0.001530604,0.00198493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007593366,"about_ca_system_score_gemma":0.0004476507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007495329,"about_ca_topic_score_gemma":0.00115333,"domain_scores_codex":[0.999823,0.00003920242,0.00002462204,0.00002713924,0.00006923642,0.00001678688],"domain_scores_gemma":[0.9998277,0.00008231176,0.00002336888,0.000008216873,0.00004681412,0.00001153125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001486165,0.0002247666,0.0002977529,0.03433223,0.0001306454,0.001353645,0.0003007684,0.00125411,0.09164482,0.0200247,0.02682042,0.8234676],"study_design_scores_gemma":[0.00001822215,0.000251821,0.0008808502,0.002107317,0.0001265822,0.003563358,0.0001291965,0.0001719692,0.01514304,0.004446531,0.9731267,0.00003448827],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003049633,0.9972637,0.0004675883,0.0001782656,0.0001774687,0.000004170155,0.00001664026,0.000008009398,0.00157921],"genre_scores_gemma":[0.001349264,0.9972405,0.0003520803,0.0001719019,0.0001035564,0.000008063382,0.00002858738,0.000002053373,0.0007439589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001579467,"threshold_uncertainty_score":0.005509377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07816343087470054,"score_gpt":0.3221778088971477,"score_spread":0.2440143780224472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}