{"id":"W2012249355","doi":"10.1002/cbic.200300591","title":"Selective Protein Degradation by Ligand‐Targeted Enzymes: Towards the Creation of Catalytic Antagonists","year":2003,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Ligand (biochemistry); Homing (biology); Chemistry; Enzyme; Catalysis; Active site; Target protein; Combinatorial chemistry; Biochemistry; Computational biology; Cell biology; Receptor; Biology; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003407929,0.0003710466,0.0002993637,0.0001502946,0.0001156741,0.0004470477,0.0003558211,0.000441603,0.0005843747],"category_scores_gemma":[0.0002125671,0.0002232162,0.0001729669,0.00009584196,0.0004244257,0.0003513384,0.000353535,0.0005246893,0.0004633795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002978795,"about_ca_system_score_gemma":0.0001871755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233976,"about_ca_topic_score_gemma":0.0003451642,"domain_scores_codex":[0.9998559,0.00002595015,0.00001215034,0.00004178358,0.00003723411,0.0000269982],"domain_scores_gemma":[0.9998919,0.00002223676,0.00003739466,0.00001316934,0.00001263161,0.00002265723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000544612,0.00001584834,0.00009850906,0.00006099429,0.00000498539,0.0000542482,0.00003664297,0.0002665143,0.9936865,0.001054142,0.00008674031,0.004580459],"study_design_scores_gemma":[0.0000324233,0.000295039,0.0002772996,0.000005705973,0.00001049449,0.0002988352,0.00001723239,0.001459049,0.991234,0.0001044072,0.006256846,0.0000087563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8937113,0.004883596,0.09393139,0.000405698,0.00006260781,0.0001668494,0.0001363111,0.0003454926,0.006356688],"genre_scores_gemma":[0.9522178,0.002766589,0.03793413,0.0002738175,0.00002075015,0.0001277993,0.0001285514,0.00004834042,0.006482326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005843747,"threshold_uncertainty_score":0.002161264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008388092280080837,"score_gpt":0.2323137933424066,"score_spread":0.2239257010623258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}