{"id":"W2012249355","doi":"10.1002/cbic.200300591","title":"Selective Protein Degradation by Ligand‐Targeted Enzymes: Towards the Creation of Catalytic Antagonists","year":2003,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Ligand (biochemistry); Homing (biology); Chemistry; Enzyme; Catalysis; Active site; Target protein; Combinatorial chemistry; Biochemistry; Computational biology; Cell biology; Receptor; Biology; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002260034,0.000159421,0.0001300681,0.0000277385,0.00009714036,0.00002253474,0.000158708,0.000154263,0.00001267106],"category_scores_gemma":[0.0004382549,0.0001262157,0.00007848939,0.0002022431,0.0001162839,0.000008230129,0.00002919209,0.00008875312,0.000006510561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003259731,"about_ca_system_score_gemma":0.0001611154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003284618,"about_ca_topic_score_gemma":0.000005234722,"domain_scores_codex":[0.9990569,0.00006308918,0.0002428204,0.0002860349,0.0001706608,0.0001805048],"domain_scores_gemma":[0.9992461,0.000007005567,0.0001639628,0.0003247903,0.0002046395,0.00005354204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003033803,0.00006804,0.0001178241,0.00002163525,0.00003520319,1.268284e-7,0.00006039927,7.871046e-7,0.9896389,0.0003228338,0.008875706,0.0008282397],"study_design_scores_gemma":[0.0004110861,0.0001206871,0.0001227954,0.0000156628,0.00001382378,0.00000411875,0.00009678472,0.00001148428,0.9800802,0.00008647927,0.01888653,0.0001503286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908674,0.00178169,0.001200422,0.0002513379,0.00007881275,0.0005479353,0.00002953969,0.00001924401,0.005223588],"genre_scores_gemma":[0.9948601,0.00004444237,0.0003250325,0.00009506226,0.00005475858,0.00008145638,0.000529032,0.00001944911,0.003990635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01001083,"threshold_uncertainty_score":0.5146927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008388092280080837,"score_gpt":0.2323137933424066,"score_spread":0.2239257010623258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}