{"id":"W2012288058","doi":"10.1016/j.bmcl.2008.05.034","title":"1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: A novel series of highly potent revertants of P-glycoprotein associated multidrug resistance","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; P-glycoprotein; Multiple drug resistance; Stereochemistry; Verapamil; Potency; Amine gas treating; Chemical synthesis; Structure–activity relationship; Tertiary amine; Transfection; Aryl; In vitro; Gene; Biochemistry; Antibiotics; Alkyl; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851503,0.0005126193,0.000444136,0.0002942039,0.0001833991,0.0001895052,0.0006927522,0.000267813,0.002196395],"category_scores_gemma":[0.0001972606,0.0001816982,0.0001754437,0.0001923524,0.0002410721,0.0002287452,0.0002843994,0.0008459614,0.00068826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529166,"about_ca_system_score_gemma":0.0001848485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003277139,"about_ca_topic_score_gemma":0.0007780248,"domain_scores_codex":[0.9999043,0.00001709453,0.000007223413,0.00001692592,0.00001910042,0.000035373],"domain_scores_gemma":[0.9999334,0.00001157063,0.00002078741,0.000007978166,0.000007044704,0.00001934743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009940213,0.0004208331,0.0002823787,0.0004165703,0.00003342935,0.0007521959,0.0002169376,0.001494585,0.9356112,0.002439437,0.001992299,0.05534604],"study_design_scores_gemma":[0.001174592,0.01098009,0.007251109,0.00006216102,0.0001055623,0.003094462,0.0001056923,0.003123719,0.9183881,0.0005962711,0.05504961,0.00006864587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498248,0.01388786,0.01075556,0.0004892349,0.0004252748,0.0002720228,0.0009161815,0.0009742736,0.02245476],"genre_scores_gemma":[0.9799917,0.007417568,0.00477464,0.0002149946,0.0001171124,0.0001648449,0.0006158529,0.00007519095,0.006628305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002196395,"threshold_uncertainty_score":0.007347703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698357699484557,"score_gpt":0.2109958016390125,"score_spread":0.194012224644167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}