{"id":"W2012293200","doi":"10.1038/nchembio.1663","title":"Combating neurodegenerative disease with chemical probes and model systems","year":2014,"lang":"en","type":"review","venue":"Nature Chemical Biology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Neurodegeneration; Systems biology; Disease; Computational biology; Chemical biology; Neuroscience; Biology; Homeostasis; Human disease; Bioinformatics; Medicine; Cell biology; Genetics; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005278214,0.001386461,0.001480504,0.001575588,0.0002140183,0.0009095338,0.00108087,0.00120132,0.002474376],"category_scores_gemma":[0.0006063048,0.0003209744,0.0004695265,0.001511678,0.0005618163,0.00149737,0.0007065167,0.001922873,0.001533141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005838207,"about_ca_system_score_gemma":0.0006844629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005781722,"about_ca_topic_score_gemma":0.001239105,"domain_scores_codex":[0.9998559,0.00001764756,0.00001337571,0.00002778613,0.00006364361,0.00002165148],"domain_scores_gemma":[0.9997935,0.00009343355,0.00003418523,0.000009589694,0.0000485046,0.0000208186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001005982,0.0001455949,0.0001139109,0.01205399,0.00008909685,0.0001809397,0.00003257158,0.0009004312,0.01024666,0.007387029,0.02809981,0.9406493],"study_design_scores_gemma":[0.00003068247,0.0001799819,0.0003062925,0.001255479,0.0001430151,0.0006439386,0.00003097426,0.0002967069,0.00418024,0.003880199,0.9890219,0.0000304522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003124804,0.9961534,0.001020995,0.0003011001,0.000333255,0.00001306812,0.00004002858,0.00002449062,0.001801185],"genre_scores_gemma":[0.001652818,0.9961293,0.0007225459,0.0002364856,0.0001555781,0.00001652749,0.00005496192,0.000003397211,0.001028427],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002474376,"threshold_uncertainty_score":0.008277595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00831535246415278,"score_gpt":0.2655198712076018,"score_spread":0.257204518743449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}