{"id":"W2012309827","doi":"10.1038/onc.2013.259","title":"Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer","year":2013,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"Amphiregulin; Lysophosphatidic acid; Transactivation; Biology; Cancer research; Epidermal growth factor receptor; Ovarian cancer; Phosphorylation; MAPK/ERK pathway; Kinase; Protein kinase B; PI3K/AKT/mTOR pathway; Cancer; Signal transduction; Internal medicine; Cell biology; Transcription factor; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165164,0.0001074648,0.0001937812,0.00009524638,0.00003950668,0.00002638689,0.0001157632,0.00008577637,0.00002225415],"category_scores_gemma":[0.0001070713,0.00009202489,0.0000354431,0.0001257662,0.00002710826,0.000006160587,0.0001205553,0.00005528403,0.000008600204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000029196,"about_ca_system_score_gemma":0.0000849869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064151,"about_ca_topic_score_gemma":0.0003316317,"domain_scores_codex":[0.9991758,0.00002704178,0.0002040621,0.0002072532,0.0001023671,0.0002834176],"domain_scores_gemma":[0.9996015,0.00001257382,0.00005089504,0.0001444431,0.00008269857,0.0001078366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003065245,0.00002144121,0.03100803,0.00002980008,0.00005968672,0.000001738909,0.00002450121,0.00001759384,0.9651244,0.00004054928,0.00009028069,0.00355138],"study_design_scores_gemma":[0.0008380761,0.0001604414,0.004205625,0.00004829824,0.000006992022,0.000001370958,0.00006218722,0.0001070195,0.9934781,0.00001304503,0.0009634658,0.000115432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978434,0.000370047,0.0001985961,0.0007733023,0.00003106485,0.0006035551,0.00001323737,0.000005703319,0.0001610362],"genre_scores_gemma":[0.9949321,0.00007376836,0.0015775,0.0001135595,0.00003630264,0.0001473673,0.00001081021,0.00001349095,0.00309506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0283537,"threshold_uncertainty_score":0.3752666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008956395804207607,"score_gpt":0.271875131352734,"score_spread":0.2629187355485264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}