{"id":"W2012309827","doi":"10.1038/onc.2013.259","title":"Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer","year":2013,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"Amphiregulin; Lysophosphatidic acid; Transactivation; Biology; Cancer research; Epidermal growth factor receptor; Ovarian cancer; Phosphorylation; MAPK/ERK pathway; Kinase; Protein kinase B; PI3K/AKT/mTOR pathway; Cancer; Signal transduction; Internal medicine; Cell biology; Transcription factor; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976387,0.0001410382,0.0001385249,0.000295368,0.0001825343,0.0002023165,0.0002196845,0.0002687008,0.0014417],"category_scores_gemma":[0.0005207619,0.00009572742,0.0001099218,0.000207698,0.0002152562,0.0001414185,0.0002932722,0.0003470931,0.0001782399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001193922,"about_ca_system_score_gemma":0.0001144203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712283,"about_ca_topic_score_gemma":0.0003455107,"domain_scores_codex":[0.9999236,0.00002031065,0.000007151083,0.00001646049,0.00001597436,0.00001652328],"domain_scores_gemma":[0.9996487,0.00006425093,0.0001834561,0.00002410352,0.0000204933,0.00005902343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002688458,0.0001870663,0.4393595,0.00006775113,0.0001701333,0.002860158,0.0001383239,0.0009522272,0.5258255,0.001652789,0.0009020494,0.02519593],"study_design_scores_gemma":[0.0001178587,0.00054203,0.8904481,0.00002009184,0.0001787795,0.008209107,0.0002830976,0.007806614,0.08672698,0.00209396,0.003549264,0.00002415677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991407,0.0001900223,0.0002815349,0.00005039571,0.000005926024,0.000002644031,0.00004076097,0.00001122665,0.0002766593],"genre_scores_gemma":[0.9993756,0.00004738704,0.0001757548,0.00002320447,0.000005660794,0.000003212297,0.00005405677,0.000004973946,0.0003101635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0014417,"threshold_uncertainty_score":0.00482291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008956395804207607,"score_gpt":0.271875131352734,"score_spread":0.2629187355485264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}