{"id":"W2012377092","doi":"10.1016/j.stemcr.2015.01.004","title":"Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans","year":2015,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Decellularization; Endoderm; Extracellular matrix; Cell biology; Biology; Induced pluripotent stem cell; Cellular differentiation; Embryonic stem cell; Stem cell; Matrix (chemical analysis); Immunology; Anatomy; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"grok","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"opus","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665743,0.0002538152,0.0001548072,0.0001354053,0.00008349054,0.0003621498,0.0001217624,0.0001926194,0.0005028843],"category_scores_gemma":[0.0001313837,0.0001132428,0.0001209489,0.00008585603,0.0001640682,0.0001766585,0.0002092573,0.0002666962,0.0001442442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001369939,"about_ca_system_score_gemma":0.0001505889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004048323,"about_ca_topic_score_gemma":0.001258738,"domain_scores_codex":[0.9998732,0.00001934457,0.00001141611,0.00001762605,0.00005172344,0.00002673736],"domain_scores_gemma":[0.9998358,0.00005218088,0.00003474478,0.00001921569,0.00002156762,0.00003629566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009828608,0.000004931894,0.000041397,0.000007641224,7.188716e-7,0.00001685538,0.000007974942,0.00002356025,0.9996017,0.00002431106,0.000002945949,0.0002582887],"study_design_scores_gemma":[0.000002989088,0.00005435638,0.001723485,0.000002460277,0.000004302624,0.00006413897,0.00001536373,0.0005997675,0.9969022,0.000014023,0.0006156598,0.000001383681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948414,0.0005378599,0.003452739,0.00002365257,0.00001044995,0.00001660198,0.0001147444,0.00003735115,0.0009652005],"genre_scores_gemma":[0.9944422,0.0003770484,0.003606477,0.00001871211,0.000005300168,0.00001636896,0.0002131785,0.00001791609,0.001302737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005028843,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02198109726647046,"score_gpt":0.255064551353381,"score_spread":0.2330834540869105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}