{"id":"W2012378217","doi":"10.1124/mol.106.029900","title":"Evidence for Direct Regulation of Myocardial Na+/H+ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel and Specific RSK Inhibitor fmk on Responses to α1-Adrenergic Stimulation","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Thomas Hospital","funders":"National Institute of General Medical Sciences; Medical Center, University of Rochester; University of Alberta","keywords":"Ribosomal s6 kinase; MAPK/ERK pathway; Phosphorylation; Kinase; Extracellular; Protein kinase A; Stimulation; Cell biology; Biology; Molecular biology; Myocyte; Biochemistry; Chemistry; Endocrinology; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660551,0.0001718179,0.0002157664,0.00006695114,0.0000900999,0.00001155364,0.00007960328,0.0001605836,0.000009299187],"category_scores_gemma":[0.00009457165,0.0001518923,0.00009137928,0.0001109201,0.00007894969,0.00001446076,0.00007873304,0.00005952803,2.113979e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002913032,"about_ca_system_score_gemma":0.00003207081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003133041,"about_ca_topic_score_gemma":0.000002912694,"domain_scores_codex":[0.9989152,0.0001607262,0.000215243,0.0003691594,0.0001568922,0.0001827798],"domain_scores_gemma":[0.9993541,0.0001569547,0.0001784736,0.0001586586,0.0001020606,0.00004975217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001630618,0.00009029207,0.0002688568,0.00006349812,0.00003768786,6.97902e-7,0.00002725725,0.001635384,0.9930866,0.00007170204,0.0004919455,0.002595462],"study_design_scores_gemma":[0.001356334,0.0007124771,0.01246252,0.0000515192,0.00007221772,0.000002287097,0.00000336447,0.001090267,0.9832026,0.00004592996,0.000852349,0.0001480924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747176,0.00158924,0.02229914,0.0001308564,0.0003513426,0.0008470693,0.00004221855,0.000006604675,0.0000159356],"genre_scores_gemma":[0.9988507,0.00008386686,0.000558435,0.0001288858,0.0001693818,0.00007893727,0.00003456942,0.00002253263,0.00007271386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02413308,"threshold_uncertainty_score":0.6193986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427190231956586,"score_gpt":0.2697783123206749,"score_spread":0.255506410001109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}