{"id":"W2012378217","doi":"10.1124/mol.106.029900","title":"Evidence for Direct Regulation of Myocardial Na+/H+ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel and Specific RSK Inhibitor fmk on Responses to α1-Adrenergic Stimulation","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Thomas Hospital","funders":"National Institute of General Medical Sciences; Medical Center, University of Rochester; University of Alberta","keywords":"Ribosomal s6 kinase; MAPK/ERK pathway; Phosphorylation; Kinase; Extracellular; Protein kinase A; Stimulation; Cell biology; Biology; Molecular biology; Myocyte; Biochemistry; Chemistry; Endocrinology; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436818,0.0004852435,0.0003475493,0.0001583474,0.0001739303,0.0002740718,0.0002433003,0.0002799984,0.002672477],"category_scores_gemma":[0.0002928765,0.0002218096,0.0003642369,0.00009599379,0.0003463342,0.0003335636,0.0002450263,0.0007023451,0.0004121994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402944,"about_ca_system_score_gemma":0.0002088385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003289265,"about_ca_topic_score_gemma":0.0007121633,"domain_scores_codex":[0.9999111,0.00001326651,0.0000106156,0.00001935251,0.00001486575,0.00003075626],"domain_scores_gemma":[0.9998701,0.00002596171,0.00003320737,0.0000249558,0.00001028815,0.00003555733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001586193,0.00008590803,0.0004598729,0.00009360797,0.00001664869,0.00008561163,0.00001922257,0.00003409415,0.9944659,0.0002128675,0.00008102193,0.002859127],"study_design_scores_gemma":[0.000306756,0.001413782,0.06909401,0.00001877806,0.0000799667,0.0008275461,0.00005260634,0.0005674554,0.9245707,0.0002490427,0.002805732,0.00001360894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986362,0.008560189,0.001812325,0.0003935327,0.00009809509,0.00002837018,0.0002718222,0.000079085,0.002394581],"genre_scores_gemma":[0.9928122,0.003722903,0.001235799,0.0001177636,0.0001054263,0.00004082022,0.0004647872,0.00001987994,0.001480355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002672477,"threshold_uncertainty_score":0.008940279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427190231956586,"score_gpt":0.2697783123206749,"score_spread":0.255506410001109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}