{"id":"W2012386044","doi":"10.1093/annonc/mdn753","title":"Stopping a trial early in oncology: for patients or for industry?","year":2009,"lang":"en","type":"letter","venue":"Annals of Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Gemcitabine; Clinical trial; Randomized controlled trial; Internal medicine; Oncology; Tamoxifen; Breast cancer; Cancer; Letrozole; Pancreatic cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.06457703,0.0008134243,0.002947145,0.001016254,0.002715622,0.006554645,0.002608082,0.05158146,0.007188267],"category_scores_gemma":[0.2967805,0.0009751024,0.00154491,0.001312535,0.008153649,0.00750708,0.002434963,0.06194447,0.005443523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00569851,"about_ca_system_score_gemma":0.009926132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004120159,"about_ca_topic_score_gemma":0.009370313,"domain_scores_codex":[0.9610069,0.0262447,0.004397607,0.00188767,0.005378925,0.00108408],"domain_scores_gemma":[0.6813036,0.2743051,0.01136413,0.005698114,0.01651404,0.01081494],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002231306,0.00006541991,0.001549674,0.000172013,0.0000682806,0.000450289,0.0001860853,0.0002514586,0.00008439405,0.02192093,0.9339451,0.04108334],"study_design_scores_gemma":[0.001195961,0.0003477801,0.002538868,0.001582239,0.0001814942,0.002424577,0.0005517443,0.004537214,0.0003484494,0.2634284,0.7226663,0.0001969717],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001435561,0.0006946378,0.0005588858,0.9941958,0.003556175,0.000007044717,0.00002383945,0.00001248281,0.0008076162],"genre_scores_gemma":[0.004147256,0.001247495,0.00226682,0.9552832,0.03444951,0.00007279826,0.00002310498,0.00004330118,0.002466559],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.935423,"threshold_uncertainty_score":0.3415201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8599858372397515,"score_gpt":0.6777961142334386,"score_spread":0.182189723006313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}