{"id":"W2012434885","doi":"10.1016/j.bmc.2009.01.078","title":"Synthesis and evaluation of imidazole–dioxolane compounds as selective heme oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Dioxolane; Stereochemistry; Selectivity; Substituent; Imidazole; Heme oxygenase; Heme; Isozyme; Chemical synthesis; Enzyme; In vitro; Medicinal chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382328,0.0003113476,0.0004087501,0.0002234997,0.0001898473,0.0002388895,0.0004027624,0.0002563486,0.00205837],"category_scores_gemma":[0.0001571724,0.0001419371,0.0001598639,0.0002209984,0.0001500137,0.0002015173,0.0001229242,0.0003441561,0.0003456178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986692,"about_ca_system_score_gemma":0.0002626897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000577023,"about_ca_topic_score_gemma":0.00127984,"domain_scores_codex":[0.9999352,0.0000107099,0.000007191413,0.00001169336,0.00001376155,0.00002154175],"domain_scores_gemma":[0.9999424,0.000007913397,0.00001321767,0.000006227637,0.00001211465,0.00001805253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008823781,0.0003319801,0.0001737626,0.0001834048,0.00002024414,0.0002308907,0.0000574104,0.0007929623,0.9799575,0.0005198572,0.0002813354,0.01656836],"study_design_scores_gemma":[0.0003582351,0.004227436,0.0009704926,0.00001425853,0.00005776914,0.0002981301,0.00002058436,0.0006928804,0.9848893,0.00006214876,0.008393377,0.00001546212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825973,0.00615436,0.005290679,0.0002200488,0.00007225882,0.0003310091,0.0007069702,0.0001059725,0.00452135],"genre_scores_gemma":[0.9798627,0.005365871,0.008668469,0.0001064904,0.00003174578,0.0001089477,0.001161035,0.00001755549,0.004677154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205837,"threshold_uncertainty_score":0.006885886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006289653211886857,"score_gpt":0.2430588100298211,"score_spread":0.2367691568179343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}