{"id":"W2012440244","doi":"10.1074/jbc.c000917200","title":"Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kinexus Bioinformatics Corporation (Canada); University of British Columbia","funders":"","keywords":"ASK1; Mitogen-activated protein kinase kinase; MAP2K7; MAP kinase kinase kinase; MAPK14; Kinase; Protein kinase A; c-Raf; Mitogen-activated protein kinase; Cyclin-dependent kinase 9; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Phosphorylation; Activator (genetics); Cyclin-dependent kinase 2; Molecular biology; Cell biology; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125813,0.0001196022,0.0001955548,0.00001436899,0.00002680297,0.00001056297,0.00007081262,0.0001866448,0.00004704085],"category_scores_gemma":[0.00007312746,0.00007890556,0.00006706178,0.00004052398,0.00006771593,0.000006579193,0.00003843888,0.0001436378,5.771593e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001141137,"about_ca_system_score_gemma":0.00002603887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003821306,"about_ca_topic_score_gemma":0.000001243223,"domain_scores_codex":[0.9993258,0.00003104075,0.0002675112,0.0001583835,0.00009483453,0.0001224137],"domain_scores_gemma":[0.9993727,0.00001829492,0.0003012559,0.000104821,0.0001073068,0.00009564234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00044845,0.0001202411,0.006424638,0.00003142725,0.00003781658,0.00003324212,0.000007927704,0.000002146637,0.9910789,0.000001234213,0.0006595966,0.001154444],"study_design_scores_gemma":[0.0005749494,0.000912349,0.001202569,0.00006807521,0.00001750171,0.0002577284,0.0001037954,0.000002808669,0.9913958,0.00001866135,0.005341338,0.0001044096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997586,0.0006357249,0.0001055065,0.00008642496,0.00004704722,0.00003907432,0.00002373572,0.000003579466,0.001472948],"genre_scores_gemma":[0.9990513,0.00035693,0.0001409144,0.00004214033,0.0002171768,0.00000187624,0.00006208764,0.00000621552,0.0001213607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005222068,"threshold_uncertainty_score":0.3217675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528003611568866,"score_gpt":0.2380021836228045,"score_spread":0.2227221475071159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}