{"id":"W2012440244","doi":"10.1074/jbc.c000917200","title":"Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kinexus Bioinformatics Corporation (Canada); University of British Columbia","funders":"","keywords":"ASK1; Mitogen-activated protein kinase kinase; MAP2K7; MAP kinase kinase kinase; MAPK14; Kinase; Protein kinase A; c-Raf; Mitogen-activated protein kinase; Cyclin-dependent kinase 9; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Phosphorylation; Activator (genetics); Cyclin-dependent kinase 2; Molecular biology; Cell biology; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001431143,0.0007082546,0.0002561756,0.0001668647,0.0002255791,0.0002272615,0.0002591797,0.0001236543,0.002421977],"category_scores_gemma":[0.00007705626,0.0001688755,0.0003332527,0.0001638426,0.0001656411,0.0002037663,0.0002679121,0.0006019644,0.0006202355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002466948,"about_ca_system_score_gemma":0.0002308934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003327625,"about_ca_topic_score_gemma":0.000703448,"domain_scores_codex":[0.9998261,0.00002345687,0.00001624817,0.00003364677,0.00004537593,0.00005517058],"domain_scores_gemma":[0.9999512,0.000008167587,0.00001147911,0.000006914898,0.000009394919,0.00001275889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009548885,0.00004983465,0.0000580987,0.0000975849,0.000008010195,0.00002716194,0.00001655623,0.00003046685,0.9979529,0.0001027763,0.00009305411,0.001467998],"study_design_scores_gemma":[0.00002157659,0.0001940181,0.002279158,0.000008143701,0.000008242133,0.0001486835,0.00001385549,0.0006695042,0.9929656,0.00007421755,0.003613692,0.000003343067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776227,0.007690117,0.009693478,0.0002915365,0.0001118776,0.00008686401,0.0006953256,0.0001782994,0.003629806],"genre_scores_gemma":[0.9769406,0.004240599,0.008815007,0.0001001815,0.0000483049,0.0002531817,0.002049589,0.00003341369,0.007519199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002421977,"threshold_uncertainty_score":0.008102298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528003611568866,"score_gpt":0.2380021836228045,"score_spread":0.2227221475071159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}