{"id":"W2012448313","doi":"10.1074/jbc.m304132200","title":"E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Osteoblast; Ubiquitin ligase; Bone morphogenetic protein; Proteasome; RUNX2; Cell biology; Core binding factor; Ubiquitin; SMAD; Transcription factor; Chemistry; Bone morphogenetic protein 2; Signal transduction; Biology; Molecular biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727605,0.000158849,0.0002336532,0.00003350079,0.00004358245,0.00003292647,0.0001075421,0.0002177508,0.00009388733],"category_scores_gemma":[0.0003540905,0.0001181729,0.00009410785,0.00007202524,0.00007222466,0.00001013808,0.00004195165,0.0001562739,0.000001653598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001768883,"about_ca_system_score_gemma":0.00004194883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001213116,"about_ca_topic_score_gemma":0.000001501813,"domain_scores_codex":[0.99903,0.00005313619,0.0003822373,0.0002154055,0.000123176,0.0001960499],"domain_scores_gemma":[0.9993666,0.0000430304,0.0002636266,0.0001068239,0.00006616948,0.0001537933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001364681,0.000107397,0.04831065,0.00001657917,0.00001421628,0.000009672002,0.00001767731,0.000002250207,0.9504547,0.00002168461,0.00008328878,0.000825448],"study_design_scores_gemma":[0.0009009964,0.0001187218,0.05831733,0.00002849258,0.00001334756,0.00006001761,0.0002316995,0.00000504358,0.9386359,0.0002071426,0.001328049,0.0001531856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957806,0.003694155,0.00006854363,0.00003048901,0.00006387873,0.00005707867,0.00003992722,0.000004204397,0.0002611011],"genre_scores_gemma":[0.9981464,0.001252668,0.0001997496,0.00003323103,0.0002178136,0.000003297257,0.00008896742,0.000008104026,0.00004975558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0118187,"threshold_uncertainty_score":0.4818951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029344508724967,"score_gpt":0.235119339282774,"score_spread":0.2148258941955244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}