{"id":"W2012458713","doi":"10.1016/j.bmc.2010.03.027","title":"Synthesis of a biologically active isomer of kotalanol, a naturally occurring glucosidase inhibitor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo; University of Toronto; Ontario Institute for Cancer Research; Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Stereocenter; Nucleophile; Thio-; Chemical synthesis; Enzyme; Ether; Biological activity; Maltase; Catalysis; Enantioselective synthesis; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009435117,0.0003060076,0.0002323687,0.000235467,0.0002116802,0.0002653548,0.0004118716,0.0002494201,0.002029072],"category_scores_gemma":[0.0001001359,0.0001311434,0.0001896243,0.0002236384,0.0001702632,0.0003226825,0.0002751461,0.0004225776,0.000818665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000403994,"about_ca_system_score_gemma":0.0007428699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000861595,"about_ca_topic_score_gemma":0.001241826,"domain_scores_codex":[0.9999226,0.00001094227,0.000007896722,0.000013855,0.00001757003,0.00002711631],"domain_scores_gemma":[0.9999607,0.000003154157,0.000006405593,0.000002894433,0.000007207086,0.00001970104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005463116,0.0002123663,0.0003029526,0.0003556087,0.00003549526,0.001043503,0.000131252,0.001165108,0.9659781,0.005058148,0.0007594542,0.02441174],"study_design_scores_gemma":[0.000228424,0.002029121,0.001316549,0.00003000362,0.00006713148,0.001266542,0.0001113963,0.001627017,0.9625035,0.000952892,0.02981562,0.00005184093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8912411,0.00924589,0.0508594,0.001298325,0.0005246522,0.0005515831,0.002986089,0.0004458347,0.04284708],"genre_scores_gemma":[0.9754006,0.003969132,0.01125474,0.0001546328,0.00003214187,0.00006402354,0.0009857942,0.00003428631,0.008104662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029072,"threshold_uncertainty_score":0.006787896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007115953240541677,"score_gpt":0.2165691443062423,"score_spread":0.2094531910657007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}