{"id":"W2012462525","doi":"10.1038/ncomms7363","title":"Intermediate DNA methylation is a conserved signature of genome regulation","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Washington University in St. Louis; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse","keywords":"DNA methylation; Epigenomics; Biology; Methylation; Genetics; Exon; Gene; Chromatin; Epigenetics of physical exercise; Epigenetics; Context (archaeology); Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004014845,0.0001115488,0.0001287431,0.00008000959,0.00006801826,0.00001466002,0.0004831004,0.0004360015,0.000009849047],"category_scores_gemma":[0.0003278487,0.000112103,0.00007618273,0.000199254,0.0001134546,0.000007935815,0.0002238519,0.0002744481,0.000005725498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002289491,"about_ca_system_score_gemma":0.0001070956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008349392,"about_ca_topic_score_gemma":0.00007756216,"domain_scores_codex":[0.9990907,0.0001746721,0.000277428,0.0001852391,0.0001634395,0.0001085317],"domain_scores_gemma":[0.9979196,0.00004333717,0.0002152917,0.001215151,0.0005287717,0.00007785985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004504058,0.00007397445,0.002357839,0.000008986608,0.0000518507,9.262349e-8,0.0003962144,0.0001302388,0.9930415,0.00109833,0.001379266,0.001416716],"study_design_scores_gemma":[0.001019203,0.0002690657,0.06489332,0.00002303393,0.00007119253,0.000001841912,0.0001979475,0.001389392,0.7501651,0.003911346,0.1777338,0.0003247248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9443284,0.04335221,0.003993597,0.002187842,0.0002696387,0.000449288,0.000109822,0.00003089945,0.005278259],"genre_scores_gemma":[0.9927635,0.0007232539,0.004926095,0.0002130281,0.00008000728,0.00001692332,0.001041715,0.00001739404,0.0002180509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2428764,"threshold_uncertainty_score":0.4571429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110333665180866,"score_gpt":0.3103838856674428,"score_spread":0.2792805490156342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}