{"id":"W2012462525","doi":"10.1038/ncomms7363","title":"Intermediate DNA methylation is a conserved signature of genome regulation","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Washington University in St. Louis; National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse","keywords":"DNA methylation; Epigenomics; Biology; Methylation; Genetics; Exon; Gene; Chromatin; Epigenetics of physical exercise; Epigenetics; Context (archaeology); Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565795,0.0001568543,0.0002910302,0.0003774464,0.000165088,0.0003149132,0.0002117212,0.0001894934,0.001002017],"category_scores_gemma":[0.0003303397,0.0001675337,0.0001700593,0.0002679374,0.0003009585,0.0002053976,0.0002864816,0.0002797375,0.0002478853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001509495,"about_ca_system_score_gemma":0.0001416855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005114524,"about_ca_topic_score_gemma":0.0008916342,"domain_scores_codex":[0.9998524,0.00001681115,0.000007941971,0.0000687901,0.00002847587,0.00002547388],"domain_scores_gemma":[0.9997696,0.00005520503,0.00007904032,0.00003646506,0.00002850451,0.00003122861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001374201,0.000005287464,0.01052747,0.00006176206,0.00002708306,0.00008261761,0.00008196482,0.0001362371,0.9832292,0.0003164907,0.00003367425,0.005360728],"study_design_scores_gemma":[0.00001131182,0.0003590694,0.3727384,0.00002434266,0.0000862629,0.002035474,0.0001624469,0.001328469,0.6160502,0.00231394,0.004868545,0.00002157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795192,0.002733514,0.01455423,0.0000981331,0.00001011543,0.00001723646,0.0007608089,0.0001841846,0.002122593],"genre_scores_gemma":[0.9954454,0.0004782882,0.003003649,0.00003600824,0.000006584258,0.000009526104,0.0004500137,0.00001593239,0.0005546918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002017,"threshold_uncertainty_score":0.003352046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110333665180866,"score_gpt":0.3103838856674428,"score_spread":0.2792805490156342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}