{"id":"W2012502527","doi":"10.1038/nrm879","title":"Life at the edge: the nuclear envelope and human disease","year":2002,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":423,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Lamin; Nuclear lamina; Biology; Envelope (radar); Housekeeping gene; Gene; Genetics; Nuclear protein; Nucleus; Cell biology; Computational biology; Gene expression; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001198652,0.001568236,0.002667752,0.001549897,0.0006616684,0.002158474,0.001955944,0.003739909,0.00322428],"category_scores_gemma":[0.00121609,0.0004022582,0.0003637019,0.002942999,0.002113044,0.003526824,0.001201053,0.003697649,0.002704292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001457117,"about_ca_system_score_gemma":0.001662689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002081655,"about_ca_topic_score_gemma":0.003792117,"domain_scores_codex":[0.9997228,0.0000537026,0.00002690301,0.00004082339,0.0001291826,0.00002660465],"domain_scores_gemma":[0.9994239,0.0002721847,0.00004684723,0.00002230396,0.0001511209,0.00008383716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001981044,0.00006757115,0.0001928607,0.006649404,0.00006740163,0.0005435178,0.0001577689,0.0006704992,0.002101835,0.011388,0.1898331,0.7881298],"study_design_scores_gemma":[0.00002376259,0.00002577841,0.0002856204,0.0009688075,0.00003698938,0.001085246,0.0001123003,0.00006220348,0.0001856286,0.005656863,0.9915426,0.00001434834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000536511,0.9968885,0.0002008963,0.0009876224,0.001121445,0.000002715206,0.000007563561,0.00001009222,0.0007275103],"genre_scores_gemma":[0.0006422928,0.9964961,0.000247271,0.0008732528,0.000998179,0.000005456986,0.00001579357,0.000001886159,0.000719707],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003739909,"threshold_uncertainty_score":0.01078629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475756050491338,"score_gpt":0.2818952250427664,"score_spread":0.267137664537853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}