{"id":"W2012511424","doi":"10.1046/j.1365-2958.2001.02404.x","title":"Physiological consequences of blocked <i>Caulobacter crescentus dnaA</i> expression, an essential DNA replication gene","year":2001,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Caulobacter crescentus; DnaA; Biology; DNA replication; Transcription (linguistics); Cell cycle; Cell division; Origin of replication; Cell biology; Origin recognition complex; Control of chromosome duplication; Pre-replication complex; Molecular biology; Genetics; Gene; Eukaryotic DNA replication; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550799,0.0006827631,0.0003797404,0.0001605097,0.0002080203,0.0004565468,0.0004559472,0.0004416241,0.0007670445],"category_scores_gemma":[0.0002151141,0.000244768,0.000228194,0.0001251951,0.0005103946,0.0002524956,0.0003453222,0.0009768626,0.0004412845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009015988,"about_ca_system_score_gemma":0.0006703342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006097008,"about_ca_topic_score_gemma":0.002910058,"domain_scores_codex":[0.9996668,0.00003609789,0.00002919059,0.00009175976,0.00008880762,0.00008738034],"domain_scores_gemma":[0.9995951,0.00006272952,0.0001351637,0.00005056414,0.00005216076,0.0001042818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004447101,0.0000136515,0.00006831409,0.00001343639,0.000001295244,0.0000224552,0.000005648622,0.00002324432,0.9996024,0.00002960279,0.00002021202,0.0001554057],"study_design_scores_gemma":[0.00000858663,0.0001015128,0.003833443,0.000003785282,0.0000048474,0.0000926831,0.00002897084,0.0005240217,0.9947686,0.00003236267,0.0005933327,0.000007884925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939897,0.0009811667,0.001954521,0.0002256564,0.00006343249,0.00003010698,0.001382883,0.00028828,0.001084296],"genre_scores_gemma":[0.9954983,0.0003012165,0.001317924,0.0001041964,0.000008866416,0.00004511029,0.0009514527,0.0001062654,0.001666683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006097008,"threshold_uncertainty_score":0.01212305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008276265642654384,"score_gpt":0.2377744100018176,"score_spread":0.2294981443591632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}